CPI-455 chemical structure
Chemical structureResearch use only
CAT. NO. DC9858Featured

CPI-455

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TotalUS$500
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Product overview

Description & Application

CPI-455 is a specific KDM5 inhibitor.

ParameterValue
Chemical NameCPI-455
CAS No.1628208-23-0
Synonyms6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile;CPI455;CPI-455;s8287;AK685833;CPI-455 hydrochloride
FormulaC16H15ClN4O
M.Wt314.7695
SMILESCl[H].O=C1C(=C(C2C([H])=C([H])C([H])=C([H])C=2[H])N=C2C(C#N)=C([H])N([H])N12)C([H])(C([H])([H])[H])C([H])([H])[H]
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

CPI-455 is a specific KDM5 inhibitor.

In Vitro

CPI-455 mediates KDM5 inhibition, elevates global levels of H3K4 trimethylation (H3K4me3) and decreases the number of DTPs in multiple cancer cell line models treated with standard chemotherapy or targeted agents[1]. CPI-455, with high measured affinity for the target KDM5 proteins. Within 24 hours, increases in H3K4me3, but not H3K4me2, are observed after exposure to either of the two active compounds, CPI-455 and CPI-766, in a dosedependent manner. IC50 calculation for KDM5 Inhibitor CPI0455 in 3 luminal breast cancer cell lines MCF-7, T-47 and EFM-19 are 35.4, 26.19 and 16.13 μM, respectively[2].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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