DC Chemicals · Product datasheet

CPI-455 — Datasheet

CAT. NO. DC9858

Product page and current package options

ParameterValue
Chemical NameCPI-455
CAS No.1628208-23-0
Synonyms6-Isopropyl-7-oxo-5-phenyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile;CPI455;CPI-455;s8287;AK685833;CPI-455 hydrochloride
FormulaC16H15ClN4O
M.Wt314.7695
SMILESCl[H].O=C1C(=C(C2C([H])=C([H])C([H])=C([H])C=2[H])N=C2C(C#N)=C([H])N([H])N12)C([H])(C([H])([H])[H])C([H])([H])[H]
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

CPI-455 is a specific KDM5 inhibitor.

In Vitro

CPI-455 mediates KDM5 inhibition, elevates global levels of H3K4 trimethylation (H3K4me3) and decreases the number of DTPs in multiple cancer cell line models treated with standard chemotherapy or targeted agents[1]. CPI-455, with high measured affinity for the target KDM5 proteins. Within 24 hours, increases in H3K4me3, but not H3K4me2, are observed after exposure to either of the two active compounds, CPI-455 and CPI-766, in a dosedependent manner. IC50 calculation for KDM5 Inhibitor CPI0455 in 3 luminal breast cancer cell lines MCF-7, T-47 and EFM-19 are 35.4, 26.19 and 16.13 μM, respectively[2].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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