MDK-5220(Orexin-2 receptor agonist) chemical structure

Chemical structureResearch use only

CAT. NO. DC9297Featured

MDK-5220(Orexin-2 receptor agonist)

Name: MDK-5220(Orexin-2 receptor agonist)
Brand: DC Chemicals
SKU: DC9297
Price: 500.0 USD

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Product overview

Description & Application

Orexin 2 Receptor Agonist is a potent (EC50 on OX2R is 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio is 70) agonist.IC50 value: 23 nM (EC50)Target: Orexin 2 ReceptorOrexin 2 Receptor Agonist shows not only potentactivity but also high selectivity for OX2R over OX1R. In CHO cells overexpressing hOX1R and HEK-293 cells overexpressing hOX2R, compound 26 displaced [125I]orexin-A in a concentration dependent manner: 26 bound to hOX2R and hOX1R with Ki of 0.14 and 0.77 μM, respectively.[1]

Parameter	Value
Chemical Name	Orexin 2 Receptor Agonist
CAS No.	1796565-52-0
Synonyms	Orexin 2 Receptor Agonist;4'-methoxy-N,N-dimethyl-3'-(N-(3-((2-(3-methylbenzamido)ethyl)amino)phenyl)sulfamoyl)-[1,1'-biphenyl]-3-carboxamide;N-[2-[3-[[5-[3-(dimethylcarbamoyl)phenyl]-2-methoxyphenyl]sulfonylamino]anilino]ethyl]-3-methylbenzamide;Nag26;Nag 26;GTPL9305;BCP17168;BDBM50121214;SB19183;compound 26 [PMID: 26267383];AK547566;3-
Formula	C32H34N4O5S
M.Wt	586.7012
SMILES	S(C1=C(C([H])=C([H])C(C2C([H])=C([H])C([H])=C(C(N(C([H])([H])[H])C([H])([H])[H])=O)C=2[H])=C1[H])OC([H])([H])[H])(N([H])C1=C([H])C([H])=C([H])C(=C1[H])N([H])C([H])([H])C([H])([H])N([H])C(C1=C([H])C([H])=C([H])C(C([H])([H])[H])=C1[H])=O)(=O)=O
Purity	>98%
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

In Vitro

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In Vivo

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References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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