DC Chemicals · Product datasheet

MDK-5220(Orexin-2 receptor agonist) — Datasheet

CAT. NO. DC9297

Product page and current package options

ParameterValue
Chemical NameOrexin 2 Receptor Agonist
CAS No.1796565-52-0
SynonymsOrexin 2 Receptor Agonist;4'-methoxy-N,N-dimethyl-3'-(N-(3-((2-(3-methylbenzamido)ethyl)amino)phenyl)sulfamoyl)-[1,1'-biphenyl]-3-carboxamide;N-[2-[3-[[5-[3-(dimethylcarbamoyl)phenyl]-2-methoxyphenyl]sulfonylamino]anilino]ethyl]-3-methylbenzamide;Nag26;Nag 26;GTPL9305;BCP17168;BDBM50121214;SB19183;compound 26 [PMID: 26267383];AK547566;3-
FormulaC32H34N4O5S
M.Wt586.7012
SMILESS(C1=C(C([H])=C([H])C(C2C([H])=C([H])C([H])=C(C(N(C([H])([H])[H])C([H])([H])[H])=O)C=2[H])=C1[H])OC([H])([H])[H])(N([H])C1=C([H])C([H])=C([H])C(=C1[H])N([H])C([H])([H])C([H])([H])N([H])C(C1=C([H])C([H])=C([H])C(C([H])([H])[H])=C1[H])=O)(=O)=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Orexin 2 Receptor Agonist is a potent (EC50 on OX2R is 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio is 70) agonist.IC50 value: 23 nM (EC50)Target: Orexin 2 ReceptorOrexin 2 Receptor Agonist shows not only potentactivity but also high selectivity for OX2R over OX1R. In CHO cells overexpressing hOX1R and HEK-293 cells overexpressing hOX2R, compound 26 displaced [125I]orexin-A in a concentration dependent manner: 26 bound to hOX2R and hOX1R with Ki of 0.14 and 0.77 μM, respectively.[1]

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Cart

Request quotation