PD-1/PD-L1 inhibitor 2(BMS-202) chemical structure
Chemical structureResearch use only
CAT. NO. DC8381Featured

PD-1/PD-L1 inhibitor 2(BMS-202)

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TotalUS$450
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Product overview

Description & Application

BMS-202 is an inhibitor of the PD-1/PD-L1 protein/protein interaction with an IC50 of 18 nM.

ParameterValue
Chemical NameN-[2-[[[2-methoxy-6-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]-3-pyridinyl]methyl]amino]ethyl]-acetamide
CAS No.1675203-84-5
SynonymsPD-L1 inhibitor 2,PD-1 inhibitor 2,PD1 inhibitor 2,PD 1 inhibitor 2,BMS 202,BMS202
FormulaC25H29N3O3
M.Wt419.52
SMILESC(NCCNCC1=CC=C(OCC2C=CC=C(C3=CC=CC=C3)C=2C)N=C1OC)(=O)C
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

BMS-202 is an inhibitor of the PD-1/PD-L1 protein/protein interaction with an IC50 of 18 nM.

In Vitro

BMS-202 inhibits PD-1/PD-Ll interaction, and may augment therapeutic immune response to a number of histologically distinct tumors. Blockade of the PD-1/PD-Ll ligation using antibodies to PD-Ll has been shown to restore and augment T cell activation in many systems[1].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Refer to the certificate supplied with your lot for batch-specific release results.

Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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