BMS-1166 (PD-1/PD-L1-IN1) chemical structure
Chemical structureResearch use only
CAT. NO. DC12058Featured

BMS-1166 (PD-1/PD-L1-IN1)

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Product overview

Description & Application

BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM.

ParameterValue
Chemical NameBMS-1166 free base
CAS No.1818314-88-3
SynonymsBMS1166,BMS 1166
FormulaC36H33ClN2O7
M.Wt641.12
SMILESO=C(O)[C@@H]1N(CC2=CC(Cl)=C(OCC3=CC=CC(C4=CC=C(OCCO5)C5=C4)=C3C)C=C2OCC6=CC=CC(C#N)=C6)C[C@H](O)C1
Purity>98%
Storage2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO

Biological Activity

BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM.

In Vitro

BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with IC50 of 1.4 nM in a homogenous time-resolved fluorescence binding assay[1]. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation. BMS-1166 dose dependently abolishes the inhibition of ECs stimulation by sPD-L1[2].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

[1]. Guzik K, et al. Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1. J Med Chem. 2017 Jul 13;60(13):5857-5867.

[2]. Skalniak L,

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO

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