Autotaxin-IN-8 chemical structure
Chemical structureResearch use only
CAT. NO. DC74479Featured

Autotaxin-IN-8

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Product overview

Description & Application

BSJ-05-037 is a potent and selective heterobifunctional degrader of ITK with DC50 of 17.6-41.8 nM in TCL lines DERL-2 and Hut78. BSJ-05-037 induces potent degradation of ITK dependent on CRBN, neddylation, and the proteasome. BSJ-05-037 induces GATA-3 loss and decreases chemotherapy resistance in vitro. BSJ-05-037 disrupts TCR signaling, downregulates the Th2-associated transcription factor GATA-3, and can overcome chemotherapy resistance in TCL models in vivo.

ParameterValue
Chemical NameAutotaxin-IN-8
CAS No.2756388-01-7
FormulaC51H59N9O10S2
M.Wt1022.2
SMILESCOC1=CC(C)=C(SC2=CN=C(NC(=O)C3=CC=C(N4CCN(CCCCCCCNC(=O)COC5=C6C(=O)N(C7CCC(=O)NC7=O)C(=O)C6=CC=C5)CC4)C=C3)S2)C=C1C(=O)N1CCN(C(C)=O)CC1
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

BSJ-05-037 is a potent and selective heterobifunctional degrader of ITK with DC50 of 17.6-41.8 nM in TCL lines DERL-2 and Hut78. BSJ-05-037 induces potent degradation of ITK dependent on CRBN, neddylation, and the proteasome. BSJ-05-037 induces GATA-3 loss and decreases chemotherapy resistance in vitro. BSJ-05-037 disrupts TCR signaling, downregulates the Th2-associated transcription factor GATA-3, and can overcome chemotherapy resistance in TCL models in vivo.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

Jiang B, et al. Cell Chem Biol. 2023 Mar 27:S2451-9456(23)00086-7.

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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