BGB 15025 chemical structure
Chemical structureResearch use only
CAT. NO. DC72741Featured

BGB 15025

Pack Sizes & Prices

TotalUS$800
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Product overview

Description & Application

BGB-15025 is a potent and selective HPK1 inhibitor. It is used in the treatment of various cancers.

ParameterValue
Chemical NameBenzamide, 4-​[5-​amino-​6-​[[1-​(1-​methyl-​4-​piperidinyl)​-​1H-​pyrazol-​4-​yl]​oxy]​-​2-​pyrazinyl]​-​N-​[2-​[(3R)​-​3-​fluoro-​1-​pyrrolidinyl]​ethyl]​-​2,​6-​dimethyl-
CAS No.2766481-17-6
SynonymsBenzamide, 4-[5-amino-6-[[1-(1-methyl-4-piperidinyl)-1H-pyrazol-4-yl]oxy]-2-pyrazinyl]-N-[2-[(3R)-3-fluoro-1-pyrrolidinyl]ethyl]-2,6-dimethyl-;BGB-15025
FormulaC28H37FN8O2
M.Wt536.64
SMILESC1CN(C)CCC1N1C=C(OC2N=C(C3=CC(C)=C(C(NCCN4CC[C@@H](F)C4)=O)C(C)=C3)C=NC=2N)C=N1
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

BGB-15025 is a potent and selective HPK1 inhibitor. It is used in the treatment of various cancers.

In Vitro

HPK1-IN-32 (Example A34, 0-2 μM, 2 h) inhibits pSLP76 activity in Jurkat cells with an IC50 of 65 nM [1].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

Target

HPK1

References & source

[1]. Sanjia XU, et al. 3-[(1h-pyrazol-4-yl)oxy]pyrazin-2-amine compounds as hpk1 inhibitor and use thereof. Patent. WO2022068848.

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

View online datasheetRequest COA / MSDS

Refer to the certificate supplied with your lot for batch-specific release results.

Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Solution calculator

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