BGB 15025 Datasheet | DC72741

BGB 15025 — Datasheet

CAT. NO. DC72741

Parameter	Value
Chemical Name	Benzamide, 4-[5-amino-6-[[1-(1-methyl-4-piperidinyl)-1H-pyrazol-4-yl]oxy]-2-pyrazinyl]-N-[2-[(3R)-3-fluoro-1-pyrrolidinyl]ethyl]-2,6-dimethyl-
CAS No.	2766481-17-6
Synonyms	Benzamide, 4-[5-amino-6-[[1-(1-methyl-4-piperidinyl)-1H-pyrazol-4-yl]oxy]-2-pyrazinyl]-N-[2-[(3R)-3-fluoro-1-pyrrolidinyl]ethyl]-2,6-dimethyl-;BGB-15025
Formula	C28H37FN8O2
M.Wt	536.64
SMILES	C1CN(C)CCC1N1C=C(OC2N=C(C3=CC(C)=C(C(NCCN4CC[C@@H](F)C4)=O)C(C)=C3)C=NC=2N)C=N1
Purity	>98%
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

BGB-15025 is a potent and selective HPK1 inhibitor. It is used in the treatment of various cancers.

In Vitro

HPK1-IN-32 (Example A34, 0-2 μM, 2 h) inhibits pSLP76 activity in Jurkat cells with an IC50 of 65 nM [1].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

Target

HPK1

References & source

[1]. Sanjia XU, et al. 3-[(1h-pyrazol-4-yl)oxy]pyrazin-2-amine compounds as hpk1 inhibitor and use thereof. Patent. WO2022068848.

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.