Product imageResearch use only

CAT. NO. DC68228

Lipid SG5

Research highlights

Dual apparent-pKa behavior was reported for the formulated fSG5 LNP system.Pulmonary luciferase expression exceeded the cited C12-200/DOTAP comparator.Functional Cre mRNA delivery was reported in mouse lung.Nrf2 mRNA delivery was evaluated in an LPS-induced acute lung-injury model.

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Product overview

Description & Application

Lipid SG5 is a dual-amine ionizable lipid developed for systemic, lung-selective mRNA delivery. Its two tertiary amines and two C16 β-hydroxy tails support stepwise protonation in the reported fSG5 LNP system. The cited preclinical study evaluated pulmonary luciferase expression, functional Cre mRNA delivery and Nrf2 mRNA delivery in an acute lung-injury model.

CAS No.	Not available
Chemical Name	Lipid SG5
SMILES	CCCCCCCCCCCCCCC(O)CN(CCN(C)C)CC(O)CCCCCCCCCCCCCC
Formula	C36H76N2O2
M.Wt	569.02
Purity	>98%
Storage	Powder: 2 years at −20 °C. In DMSO: 2 weeks at 4 °C or 6 months at −80 °C.
Shipping condition	Ships from Shanghai. Contact us to confirm the appropriate transport condition for the current batch.
Product classification	Cationic/Ionizable Lipids; Ionizable Lipids for lung-targeted delivery

Literature-reported formulation and performance

Formulation IDfSG5

CargoReporter mRNA, Cre mRNA or Nrf2 mRNA, depending on the study

Administration routeSystemic administration in preclinical mouse studies

Target tissueLung

Literature-reportedPulmonary reporter expressionHigher than the cited C12-200/DOTAP comparator

Literature-reportedCre mRNA deliveryFunctional pulmonary delivery reported

Literature-reportedAcute lung injuryNrf2 mRNA delivery reduced edema and inflammatory injury in the cited model

Literature Data DisclaimerThese results apply only to the cited fSG5 formulations and animal models. They are not properties of the neat lipid alone and are not a guarantee of performance.

Cited literatureLim SG, Lee M, Wang Y, et al. Dual pKa Lipid Nanoparticles for Lung-tropic mRNA Delivery and pH-Programmed Endosomal Escape. Advanced Science. 2026:e77387.

SDSMSDSAvailable upon requestRequest document →

COACOABatch-specific certificateRequest document →

DATADatasheetProduct information pageRead online →

Laboratory planning

Solution Calculators

The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.

Mass = concentration × volume × molecular weight

MassConcentrationVolumeMolecular weightg/mol

Enter any three values to calculate the fourth.

C₁V₁ = C₂V₂

C₁mMV₁mLC₂mMV₂mL

Enter any three values to calculate the fourth.

Preparing stock solutions

Quick preparation table

Solvent volumes update from the molecular weight above.

Mass	1 mM	5 mM	10 mM
10 mg	11.6504 mL	2.3301 mL	1.1650 mL
25 mg	29.1260 mL	5.8252 mL	2.9126 mL
50 mg	58.2520 mL	11.6504 mL	5.8252 mL
100 mg	116.5039 mL	23.3008 mL	11.6504 mL
250 mg	291.2599 mL	58.2520 mL	29.1260 mL

Need a different pack size or technical document?

Contact our team with the catalog number and requested quantity.

Handling guidance

Shipping, storage and sampling

How is the lipid shipped, and how should I store it?

We generally ship the neat (undissolved) lipid compound rather than an ethanol solution. The neat lipid is stable during transport with ice packs, and shipments originate from Shanghai. Pure form: store at −20 °C for up to 1 year. In solvent: store at −80 °C for up to 6 months or at −20 °C for up to 1 month. Keep sealed and protected from light. Avoid repeated thaw cycles for best results.

Pure lipid or solution — which should I choose?

Pure lipid is generally more stable during shipping and storage, so we usually recommend the pure form. A solution in ethanol or chloroform can be supplied when required by your workflow. Tell us the intended application, solvent and target concentration so the most suitable format can be confirmed.

How should I measure a small amount of oily or viscous lipid?

Ionizable lipids are often oily liquids or viscous semisolids, so material can be lost during repeated weighing or transfer. For a small pack, dissolve the entire quantity and aliquot it volumetrically. For example, add 1 mL ethanol to 25 mg lipid to prepare a 25 mg/mL stock, then use a pipette to withdraw the required amount. For quantities above 100 mg, direct weighing with an analytical balance may be more practical. Always confirm solvent compatibility and solubility first.

Can you support formulation optimization and scale-up?

Yes. Share the RNA cargo, target tissue, administration route, formulation method and assay plan. Our team can discuss starting molar ratios, N/P ratio and scale-up requirements for research workflows.