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DC68228 · Updated 24 October 2026

Lipid SG5
Formulation & Performance

This edition organizes the previously reviewed, source-linked product record. It is not a new independent review of every paper or supporting file. Reported and calculated values retain their original labels.

Literature-reported formulation and performance

fSG5
Reporter mRNA, Cre mRNA or Nrf2 mRNA, depending on the study
Systemic administration in preclinical mouse studies
Lung
Literature-reportedHigher than the cited C12-200/DOTAP comparator
Literature-reportedFunctional pulmonary delivery reported
Literature-reportedNrf2 mRNA delivery reduced edema and inflammatory injury in the cited model
Literature Data DisclaimerThese results apply only to the cited fSG5 formulations and animal models. They are not properties of the neat lipid alone and are not a guarantee of performance.
Cited literatureLim SG, Lee M, Wang Y, et al. Dual pKa Lipid Nanoparticles for Lung-tropic mRNA Delivery and pH-Programmed Endosomal Escape. Advanced Science. 2026:e77387.