CAT. NO. DC68030Featured

C6mPhE-383

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Ships from ShanghaiIce-pack transportPure lipid recommended

Product overview

Description & Application

C6mPhE-383 is a meta-substituted aromatic, disulfide-containing ionizable lipid based on the 383 polyamine core. In the cited mouse study, LNPs containing C6mPhE-383 delivered reporter mRNA to draining lymph nodes after intramuscular administration with reduced liver accumulation and transfection relative to SM-102 LNPs. The investigators also evaluated this lipid in an mRNA SARS-CoV-2 spike vaccination model and reported antigen-specific antibody and T-cell responses.

CAS No.	Not available
Chemical Name	3,3′,3″,3‴-((piperazine-1,4-diylbis(propane-3,1-diyl))bis(azanetriyl))tetrakis(1-(3-(hexyldisulfaneyl)phenoxy)propan-2-ol)
Synonyms	C6mPhE383;C6mPhE 383
SMILES	CCCCCCSSc1cccc(OCC(O)CN(CCCN2CCN(CCCN(CC(O)COc3cccc(SSCCCCCC)c3)CC(O)COc3cccc(SSCCCCCC)c3)CC2)CC(O)COc2cccc(SSCCCCCC)c2)c1
Formula	C70H112N4O8S8
M.Wt	1394.22
Purity	>95% by ELSD-HPLC
Storage	Pure form: −20 °C, 1 year; In solvent: −80 °C, 6 months; −20 °C, 1 month. Sealed and protected from light.
Shipping condition	Ships from Shanghai. Pure lipid is stable during ice-pack transport.
Publication	Yamagata HM, et al. Liver-Detargeted Aromatic Bioreducible mRNA Lipid Nanoparticles Confer Lymph Node Tropism and Robust Antigen-Specific Immunity. J Am Chem Soc (2026). doi:10.1021/jacs.6c00080

Published C6mPhE-383 LNP composition

Component	mol%	Role
C6mPhE-383	35	Ionizable lipid
DOPE	16	Helper phospholipid
Cholesterol	46.5	Sterol
C14-PEG2000	2.5	PEG lipid
Total	100	Supporting Information §1.10

CargoLuciferase or SARS-CoV-2 S2P mRNA

PreparationMicrofluidic mixing; ethanol:aqueous 1:3

Lipid:mRNA mass ratio10:1

ModelMice, intramuscular administration

N/P ratioNot reported

Results in the published mouse study

Reporter mRNA delivery

At 0.05 mg/kg luciferase mRNA (1 µg) and 6 h after intramuscular dosing, the aroLNP series showed lymph-node transfection with less liver signal than the SM-102 comparator. C6mPhE-383 was selected for follow-up biodistribution experiments.

Distribution

DiR-labeled C6mPhE-383 LNPs accumulated in draining iliac and inguinal lymph nodes with lower hepatic accumulation than SM-102 LNPs after intramuscular injection.

Vaccination

In a mouse SARS-CoV-2 spike mRNA prime–boost study (0.25 mg/kg, 5 µg mRNA; doses 3 weeks apart), C6mPhE-383 LNPs produced anti-RBD IgG and antigen-responsive T-cell responses. Spleens and serum were assessed 2 weeks after boosting.

Systemic cytokines

In a separate luciferase mRNA experiment, circulating IL-6, TNF and IFN-γ were lower for C6mPhE-383 LNPs than for the SM-102 LNP comparator under the reported conditions.

Primary publicationYamagata HM, et al. Liver-Detargeted Aromatic Bioreducible mRNA Lipid Nanoparticles Confer Lymph Node Tropism and Robust Antigen-Specific Immunity. J Am Chem Soc (2026). doi:10.1021/jacs.6c00080. View paper. Formulation and synthesis: Supporting Information pp. 3 and 44; delivery and distribution: Figs. 2 and 4; vaccination and cytokines: Figs. 5 and 6.

Laboratory planning

Solution Calculators

The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.

Mass = concentration × volume × molecular weight

MassConcentrationVolumeMolecular weightg/mol

Enter any three values to calculate the fourth.

C₁V₁ = C₂V₂

C₁mMV₁mLC₂mMV₂mL

Enter any three values to calculate the fourth.

Preparing stock solutions

Quick preparation table

Solvent volumes update from the molecular weight above.

Mass	1 mM	5 mM	10 mM
10 mg	7.1725 mL	1.4345 mL	0.7172 mL
25 mg	17.9311 mL	3.5862 mL	1.7931 mL
50 mg	35.8623 mL	7.1725 mL	3.5862 mL
100 mg	71.7246 mL	14.3449 mL	7.1725 mL
250 mg	179.3115 mL	35.8623 mL	17.9311 mL

Need a different pack size or technical document?

Contact our team with the catalog number and requested quantity.

Handling guidance

Shipping, storage and sampling

How is the lipid shipped, and how should I store it?

We generally ship the neat (undissolved) lipid compound rather than an ethanol solution. The neat lipid is stable during transport with ice packs, and shipments originate from Shanghai. Pure form: store at −20 °C for up to 1 year. In solvent: store at −80 °C for up to 6 months or at −20 °C for up to 1 month. Keep sealed and protected from light. Avoid repeated thaw cycles for best results.

Pure lipid or solution — which should I choose?

Pure lipid is generally more stable during shipping and storage, so we usually recommend the pure form. A solution in ethanol or chloroform can be supplied when required by your workflow. Tell us the intended application, solvent and target concentration so the most suitable format can be confirmed.

How should I measure a small amount of oily or viscous lipid?

Ionizable lipids are often oily liquids or viscous semisolids, so material can be lost during repeated weighing or transfer. For a small pack, dissolve the entire quantity and aliquot it volumetrically. For example, add 1 mL ethanol to 25 mg lipid to prepare a 25 mg/mL stock, then use a pipette to withdraw the required amount. For quantities above 100 mg, direct weighing with an analytical balance may be more practical. Always confirm solvent compatibility and solubility first.

Can you support formulation optimization and scale-up?

Yes. Share the RNA cargo, target tissue, administration route, formulation method and assay plan. Our team can discuss starting molar ratios, N/P ratio and scale-up requirements for research workflows.

C6mPhE-383

Pack size & price

Description & Application

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