GSK620 chemical structure
Chemical structureResearch use only
CAT. NO. DC42300Featured

GSK620

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TotalUS$600
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Product overview

Description & Application

GSK620 is a potent and orally active pan-BD2 with excellent broad selectivity, developability and in vivo oral pharmacokinetics. GSK620 is highly selective for the BET-BD2 family of proteins, with >200-fold selectivity over all other bromodomains. GSK620 shows an anti-inflammatory phenotype in human whole blood.

ParameterValue
Chemical NameGSK620
CAS No.2088410-46-0
SynonymsGSK620;GSK-620;GSK 620
FormulaC18H19N3O3
M.Wt325.36
SMILESO=C(C1=CC(C(NC2CC2)=O)=CN(CC3=CC=CC=C3)C1=O)NC
Purity>98%
StoragePlease store the product under the recommended conditions in the Certificate of Analysis.

Biological Activity

GSK620 is a potent and orally active pan-BD2 with excellent broad selectivity, developability and in vivo oral pharmacokinetics. GSK620 is highly selective for the BET-BD2 family of proteins, with >200-fold selectivity over all other bromodomains. GSK620 shows an anti-inflammatory phenotype in human whole blood.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

[1]. Seal JT, et al. The Optimization of a Novel, Weak Bromo and Extra Terminal Domain (BET) Bromodomain Fragment Ligand to a Potent and Selective Second Bromodomain (BD2) Inhibitor. J Med Chem. 2020;63(17):9093-9126.

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

Please store the product under the recommended conditions in the Certificate of Analysis.

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