PF-04971729 (Ertugliflozin) chemical structure
Chemical structureResearch use only
CAT. NO. DC3108Featured

PF-04971729 (Ertugliflozin)

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Product overview

Description & Application

Ertugliflozin (PF-04971729) is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), with an IC50 of 0.877 nM for h-SGLT2[1]. A drug for the treatment of type 2 diabetes mellitus[2].

ParameterValue
Chemical NameErtugliflozin
CAS No.1210344-57-2
SynonymsPF04971729,PF 04971729 (Ertugliflozin)
FormulaC22H25ClO7
M.Wt436.885
SMILESC1=CC([C@@]23O[C@@](CO)(CO2)[C@H](O)[C@@H](O)[C@@H]3O)=CC(CC2=CC=C(OCC)C=C2)=C1Cl
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Ertugliflozin (PF-04971729) is a potent, selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2), with an IC50 of 0.877 nM for h-SGLT2[1]. A drug for the treatment of type 2 diabetes mellitus[2].

In Vitro

Ertugliflozin (PF-04971729) demonstrates >2000-fold selectivity for SGLT2 inhibition (relative to SGLT1) in vitro[3].

In Vivo

Ertugliflozin (PF-04971729) reveals a concentration-dependent glucosuria after oral administration to rats[3].

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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