Naltrexone chemical structure
Chemical structureResearch use only
CAT. NO. DC22472Featured

Naltrexone

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Product overview

Description & Application

A potent, competitive antagonist for μ, κ, δ, and σ-opioid receptors with Ki of 0.0825 nM, 0.509 nM, and 8.02 nM, for MOR, KOR, and DOR, respectively; also inhibits IL-6 and TNFα production in human immune cell subsets following stimulation with ligands for intracellular TLRs; a TLR-4 antognist that inhibits LPS-induced TLR4 downstream NO production in microglia BV-2 cells (IC50=105 uM).AlcoholismApproved

ParameterValue
Chemical NameNaltrexone
CAS No.16590-41-3
SynonymsNaltrexone;17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one;Naltrexone (base, anhydrous);Naltrexone solution;(5α)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one;celupan;Depotrex;en1639;en1939;Naltrel;NeMexin;trexan;Trexonil;Um-792;C07253
FormulaC20H23NO4
M.Wt341.40092
SMILESC1CC1CN2CC[C@@]34C5=C6C=CC(=C5O[C@H]4C(=O)CC[C@]3([C@H]2C6)O)O
Purity98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

A potent, competitive antagonist for μ, κ, δ, and σ-opioid receptors with Ki of 0.0825 nM, 0.509 nM, and 8.02 nM, for MOR, KOR, and DOR, respectively; also inhibits IL-6 and TNFα production in human immune cell subsets following stimulation with ligands for intracellular TLRs; a TLR-4 antognist that inhibits LPS-induced TLR4 downstream NO production in microglia BV-2 cells (IC50=105 uM).AlcoholismApproved

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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