Alflutinib (AST2818 mesylate) chemical structure

Chemical structureResearch use only

CAT. NO. DC12072Featured

Alflutinib (AST2818 mesylate)

Name: Alflutinib (AST2818 mesylate)
Brand: DC Chemicals
SKU: DC12072
Price: 850.0 USD

Pack Sizes & Prices

TotalUS$850

We match the best price and quality on market.

Product overview

Description & Application

AST2818 mesylate is an EGFR inhibitor.

Parameter	Value
Chemical Name	AST2818 ;AST-2818 ;AST 2818
CAS No.	2130958-55-1
Synonyms	AST2818 ;AST-2818 ;AST 2818
Formula	C29H35F3N8O5S
M.Wt	664.7
SMILES	C=CC(NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OCC(F)(F)F)N=C1N(CCN(C)C)C)=O.CS(=O)(O)=O
Purity	>98%
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

AST2818 mesylate is an EGFR inhibitor.

In Vitro

AST2818 mesylate is designed to inhibit EGFR active mutations as well as the T790M acquired resistant mutation[1].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

[1]. Y.Shi, et al. P2.03-028 Third Generation EGFR Inhibitor AST2818 (Alflutinib) in NSCLC Patients with EGFR T790M Mutation: A phase1/2 Multi-Center Clinical Trial. J Thorac Oncol. 2017 Nov, 12(11): S213

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

View online datasheet Request COA / MSDS

Refer to the certificate supplied with your lot for batch-specific release results.

Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Solution calculator

Related research products

DC5090

WZ4002

WZ4002 is a mutant selective EGFR inhibitor with IC50s of 2, 8, 3 and 2 nM for EGFRL858R, EGFRL858R/T790M, EGFRE746_A750 and EGFRE746_A750/T790M, respectively.

View activity & prices

DC3138

Canertinib dihydrochloride

Canertinib dihydrochloride (CI-1033;PD-183805) is a potent and irreversible EGFR inhibitor; inhibits cellular EGFR and ErbB2 autophosphorylation with IC50s of 7.4 and 9 nM.

View activity & prices

DC5021

PD153035 HCl (SU-5271, AG1517)

PD153035 (ZM 252868;AG 1517;Tyrphostin AG 1517;SU 5271) is a potent EGFR inhibitor with Ki and IC50 of 6 and 25 pM, respectively.

View activity & prices

DC7106

Rociletinib (CO-1686)

Rociletinib (CO-1686) is an orally delivered kinase inhibitor that specifically targets the mutant forms of EGFR including T790M, and the Ki values for EGFRL858R/T790M and EGFRWT are 21.5 nM and 303.3 nM, respectively.

View activity & prices

DC8052

AZ5104

AZ-5104 is an active, demethylated metabolite of AZD 9291. AZ-5104 is an EGFR inhibitor with IC50s of 1, 6, 1, 25 and 7 nM for EGFRL858R/T790M, EGFRL858R, EGFRL861Q, EGFR and ErbB4, respectively.

View activity & prices

DC7006

AZD-9291(Osimertinib)

Osimertinib (AZD-9291) is an irreversible and mutant selective EGFR inhibitor with IC50s of 12 and 1 nM against EGFRL858R and EGFRL858R/T790M, respectively.

View activity & prices

DC1091

PF-299804 (Dacomitinib,PF-00299804)

Dacomitinib is a specific and irreversible inhibitor of the ERBB family of kinases with IC50s of 6 nM, 45.7 nM and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively.

View activity & prices

DC7225

Pelitinib (EKB-569; WAY-EKB 569)

Pelitinib (EKB-569;WAY-EKB 569) is an irreversible inhibitor of EGFR with an IC50 of 38.5 nM; also slightly inhibits Src, MEK/ERK and ErbB2 with IC50s of 282, 800, and 1255 nM, respectively.

View activity & prices