DC Chemicals · Product datasheet

Alflutinib (AST2818 mesylate) — Datasheet

CAT. NO. DC12072

Product page and current package options

ParameterValue
Chemical NameAST2818 ;AST-2818 ;AST 2818
CAS No.2130958-55-1
SynonymsAST2818 ;AST-2818 ;AST 2818
FormulaC29H35F3N8O5S
M.Wt664.7
SMILESC=CC(NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OCC(F)(F)F)N=C1N(CCN(C)C)C)=O.CS(=O)(O)=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

AST2818 mesylate is an EGFR inhibitor.

In Vitro

AST2818 mesylate is designed to inhibit EGFR active mutations as well as the T790M acquired resistant mutation[1].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

[1]. Y.Shi, et al. P2.03-028 Third Generation EGFR Inhibitor AST2818 (Alflutinib) in NSCLC Patients with EGFR T790M Mutation: A phase1/2 Multi-Center Clinical Trial. J Thorac Oncol. 2017 Nov, 12(11): S213

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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