STING inhibitor C-176 chemical structure
Chemical structureResearch use only
CAT. NO. DC10960Featured

STING inhibitor C-176

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TotalUS$450
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Product overview

Description & Application

C-176 is a strong and covalent mouse STING inhibitor.

ParameterValue
Chemical NameN-(4-iodophenyl)-5-nitrofuran-2-carboxamide
CAS No.314054-00-7
FormulaC11H7IN2O4
M.Wt358.091
SMILESO1C([N+]([O-])=O)=CC=C1C(NC1=CC=C(I)C=C1)=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

C-176 is a strong and covalent mouse STING inhibitor.

In Vitro

C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. Pretreatment with C-176 markedly reduce the CMA-mediated induction of serum levels of type I IFNs and IL-6[1].

In Vivo

Notably, treatment of Trex1−/− mice with C-176 resulted in a significant reduction in serum levels of type I IFNs and in a strong suppression of inflammatory parameters in the heart. Wild-type mice on a two-week treatment with C-176 show no evident signs of overt toxicity. We next conducted a three-month trial with C-176 in Trex1−/− mice, which demonstrated marked amelioration of various signs of systemic inflammation[1].

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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