H-151 chemical structure
Chemical structureResearch use only
CAT. NO. DC10876Featured

H-151

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TotalUS$1,600
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Product overview

Description & Application

H-151 is a highly potent, selective and covalent antagonist of STING, reduces TBK1 phosphorylation and suppresses human STING palmitoylation[1].

ParameterValue
Chemical Name1-(4-Ethylphenyl)-3-(1H-indol-3-yl)urea
CAS No.941987-60-6
Synonyms1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea;N-(4-ethylphenyl)-N'-1H-indol-3-yl-urea;H 151;H151;STING antagonist;3-(4-ethylphenyl)-1-(1H-indol-3-yl)urea;H151 pound>>H 151;GTPL10122;BCP29964;s6652;AK00799464
FormulaC17H17N3O
M.Wt279.3364
SMILESO=C(N([H])C1C([H])=C([H])C(=C([H])C=1[H])C([H])([H])C([H])([H])[H])N([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C21
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

H-151 is a highly potent, selective and covalent antagonist of STING, reduces TBK1 phosphorylation and suppresses human STING palmitoylation[1].

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

[1]. Haag SM, et al. Targeting STING with covalent small-molecule inhibitors. Nature. 2018 Jul;559(7713):269-273.

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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