Bisindolylmaleimide X(Ro 31-8425) chemical structure
Chemical structureResearch use only
CAT. NO. DC10052Featured

Bisindolylmaleimide X(Ro 31-8425)

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TotalUS$750
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Product overview

Description & Application

Bisindolylmaleimide X is a cell-permeable, reversible, ATP-competitive protein kinase C (PKC) inhibitor (IC50 = 15 nM, rat brain PKC).

ParameterValue
Chemical Name3-​[8-​(aminomethyl)-​6,​7,​8,​9-​tetrahydropyrido[1,​2-​a]indol-​10-​yl]-​4-​(1-​methyl-​1H-​indol-​3-​yl)-​1H-​pyrrole-​2,​5-​dione,​ monohydrochloride
CAS No.1241725-89-2
SynonymsBIM X,Ro 31-8425 Ro 31-8425
FormulaC26H24N4O2
M.Wt424.49
SMILESCN1C2=CC=CC=C2C=C1C3=C(C(=O)NC3=O)C4=C5CC(CCN5C6=CC=CC=C64)CN
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Bisindolylmaleimide X is a cell-permeable, reversible, ATP-competitive protein kinase C (PKC) inhibitor (IC50 = 15 nM, rat brain PKC).

In Vitro

Bisindolylmaleimide X is a cell-permeable, reversible, ATP-competitive protein kinase C (PKC) inhibitor (IC50?= 15 nM, rat brain PKC).It has been shown to inhibit PKCα, βI, βII, γ, and ε with IC50?values of 8, 8, 14, 13, and 39 nM, respectively. It has also been identified as an inhibitor of Cdk2 (IC50?= 200 nM) and GSK3α/β. This compound has been used to activate mesenchymal stem cells, increase the surface expression of homing ligands that bind to intercellular adhesion molecule, and target delivery of these cells to sites of inflammation

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Solution calculator

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