DC Chemicals · Product datasheet

S-2765(FXa substrate,Z-D-Arg-Gly-Arg-pNA Dihydrochloride) — Datasheet

CAT. NO. DC9806

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ParameterValue
Chemical NameZ-D-Arg-Gly-Arg-pNA Dihydrochloride
CAS No.113711-77-6
SynonymsL-Argininamide,N2-[(phenylmethoxy)carbonyl]-D-arginylglycyl-N-(4-nitrophenyl)-, hydrochloride(1:2);L-Argininamide,N2-[(phenylmethoxy)carbonyl]-D-arginylglycyl-N-(4-nitrophenyl)-, hydrochloride(...;Z-D-ARG-GLY-ARG-PNA · 2 HCL;Chromogenic substrate for thrombin S-2238;Z-D-Arg-Gly-Arg-pNA;S-2765(FXa substrate);Z-D-ARG-GLY-ARG-PNA 2 HCL;L-Argininamide, N2-[(phenylmethoxy)carbonyl]-D-arginylglycyl-N-(4-nitrophenyl)-, hydrochloride (1:2);CID 145710077;Chromogenix S-2238;benzyl N-[(2R)-5-(diaminomethylideneamino)-1-[[2-[[(2S)-5-(diaminomethylideneamino)-1-(4-nitroanilino)-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxopentan-2-yl]carbamate;CHROMOGENIX;S2765 ;S 2765;Z-D-ARG-GLY-ARG-PNA.2HCL;Z-RGR-PNA
FormulaC28H40ClN11O7
M.Wt678.13970375061
SMILESCl.O=C([C@@H](CCC/N=C(\N)/N)NC(=O)OCC1C=CC=CC=1)NCC(N[C@H](C(NC1C=CC(=CC=1)[N+](=O)[O-])=O)CCC/N=C(\N)/N)=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

S-2765, which is specific to activated factor X (FXa), is a short peptide covalently bound to pNA (4-nitroaniline). When attacked by FXa, it releases a free pNA which could be detected by a spectrophotometer at 405 nm.S-2765 is mainly used in anti-FXa activity assay of heparin. S-2765 can be used in many applications, such as: 1:Anti-factor Xa activity to anti-factor IIa activity ratios of heparin and LMWHs. 2: Anti-factor Xa activities of heparin and LMWHs. 3: Activities of antithrombin and coagulation factors. 4: Anti-factor Xa activities of heparin and LMWHs in human plasma. 5: Production of kits for automated blood analyzers. 6: Evaluation of potential anticoagulants from chemical synthesis, bacterial fermentation and animal tissues.

In Vitro

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In Vivo

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References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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