DC Chemicals · Product datasheet

Cyclo(RGDyK) — Datasheet

CAT. NO. DC8399

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ParameterValue
Chemical NameCyclo(RGDyK) trifluoroacetate
CAS No.250612-42-1
SynonymsCyclic Arg-Gly-Asp-D-Tyr-Lys;Cyclo(RGDyK);AK685805;Cyclo(RGDyK) trifluoroacetate
FormulaC31H43F6N9O12
M.Wt847.716648340225
SMILESFC(C(=O)O)(F)F.FC(C(=O)O)(F)F.O=C1C(CCCCN)NC(C(CC2C=CC(=CC=2)O)NC(C(CC(=O)O)NC(CNC(C(CCC/N=C(\N)/N)N1)=O)=O)=O)=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.

In Vitro

Cyclo(RGDyK) (c(RGDyK(SAA)) shows high affinity and selectivity for αVβ3 over αVβ5 (IC50=4000 nM) and αIIbβ3 (IC50=3000 nM)[1].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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