DC Chemicals · Product datasheet

K02288 — Datasheet

CAT. NO. DC7742

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ParameterValue
Chemical Name3-[6-Amino-5-(3,4,5-Trimethoxyphenyl)pyridin-3-Yl]phenol
CAS No.1431985-92-0
SynonymsK 02288;3-[6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol;K02288​;K-02288;3-[(6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenol;3-[6-Amino-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]-phenol;3-[6-Amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenol;K02288;3-(6-amino-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl)phenol;A3F;SYN5187;AOB4291;HMS3653M16;BDBM102619;K02288a;BCP09946;s7359;K 02288a;FD5034;SB19486;BC600483;AK175599;Y1876;K02288, >98% (HPLC);SW220200-1;A14311;Phenol
FormulaC20H20N2O4
M.Wt352.3838
SMILESO(C([H])([H])[H])C1C(=C(C([H])=C(C=1[H])C1=C(N([H])[H])N=C([H])C(C2C([H])=C([H])C([H])=C(C=2[H])O[H])=C1[H])OC([H])([H])[H])OC([H])([H])[H]
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

K02288 is a potent inhibitor of ALK, and inhibits ALK1/2/3/6 with IC50s of 1.8/1.1/34.4/6.3 nM; K02288 is less potent against ALK4/5, with IC50s of 302 nM and 321 nM.

In Vitro

K02288 reduces a robust phosphorylation of Smad1/5/8 induced by BMP4 stimulation, with an apparent IC50 of 100 nM. K02288 causes near complete inhibition of Smad2 phosphorylation at 0.5 µM[1]. K02288 binds to ALK1 in an ATP-mimetic fashion with two hydrogen bonds to the kinase hinge. K02288 also inhibits BMP9-ALK1 signalling, and induces a hypersprouting phenotype in HUVECs[2].

In Vivo

K02288 (1 µM) induces dysfunctional angiogenesis in a chick embryo CAM model[2].

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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