DC Chemicals · Product datasheet

Amisulpride — Datasheet

CAT. NO. DC31537

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ParameterValue
Chemical NameAmisulpride
CAS No.71675-85-9
SynonymsAmisulpride;AMINOSULTOPRIDE;SOLIAN;3-Amino-6-isopropylpyridine;4-amino-N-[(1-ethylpyrrolidin-2-yl)methyl]-5-ethylsulfonyl-2-methoxybenzamide;: Amisulpride;4-amino-N-[(1-ethyl-2-pyrrolidin-yl)methyl]-5-(ethyl-sulfonyl)-2--methoxybenzamide;Amisulpiride;Amisulprida;Amisulpridum;Amisulpridum [INN-Latin];DAN 2163;DAN-2163;Deniban;Socian;4-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxybenzamide;4-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-ethylsulfonyl-2-methoxybenzamide;NCGC00092310-06;CCG-100860;PS24 - Amisulpride;A837282;Amisulpride, 1mg/ml in Methanol;NC00110;Amisulpride- Bio-X;AMISULPRIDE [ORANGE BOOK];AB00639933-09;Deniban (TN);EINECS 275-831-7;APD-421;71675-85-9 (free base);HMS3263D07;HMS3657E11;Amisulpride for system suitability;Amisulpride [INN];SW197490-3;AKOS005567252;Amisulprida [INN-Spanish];DTXCID3022613;HB1879;HMS3413G07;4-Amino-N-[(1-Ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)- 2-methoxybenzamide;AB00639933-07;SMR000449309;N05AL05;UNII-8110R61I4U;HMS2051K10;NCGC00092310-02;NCGC00092310-04;NTJOBXMMWNYJFB-UHFFFAOYSA-N;BCPP000404;NCGC00092310-16;MLS000758258;D07310;Barhemsys (TN);AMISULPRIDE [WHO-DD];NSC760085;HMS3393K10;Sulpitac;AB00639933_10;SDCCGSBI-0633795.P001;AMISULPRIDE [EP MONOGRAPH];Amisulpride, European Pharmacopoeia (EP) Reference Standard;C17H27N3O4S;CCG-222437;4-Amino-N-[(1-ethyl-2-pyrrolidinyl) methyl]-5-(ethylsulfonyl)-2-benzamide;CHEMBL243712;BDBM81790;Q418785;EN300-18166870;NSC-760085;NS00000416;SY052770;4-Amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-benzamide;SL-91.1077;S1280;Amisulpride; 4-Amino-N-[[(2RS)-1-ethylpyrrolidin-2-yl]methyl]-5-(ethylsulfonyl)-2-methoxybenzamide;Barhemsys;MFCD00866691;DB06288;HMS3677G07;HMS3713N06;GTPL963;HMS3268L09;Tox21_501133;NSC_2159;71675-85-9;AMISULPRIDE (EP MONOGRAPH);NCGC00092310-03;SR-01000759303;W-104511;NCGC00261818-01;LP01133;CS-1791;BRD-A60197193-001-05-4;Amisulpridum (INN-Latin);Benzamide, 4-amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxy-;Amisulpride free base;Amisulpride, >=98% (HPLC);CAS_71675-85-9;4-amino-N-((1-ethylpyrrolidin-2-yl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide;4-azanyl-N-[(1-ethylpyrrolidin-2-yl)methyl]-5-ethylsulfonyl-2-methoxy-benzamide;HMS3369K09;Tox21_113392;AC-6820;MLS000759450;BCP9000294;4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-anisamid;4-Amino-N-((1-ethyl-2-pyrrolidinyl)methyl)-5-(ethylsulfonyl)-2-methoxybenzamide;HMS2235M16;Amisulpride 100 microg/mL in Acetonitrile;Amisulpride [INN:BAN];BA164158;HY-14545;BCP02089;MLS001424039;AS-13890;CHEBI:64045;Amisulpride (INN);(+-)-amisulpride;Pharmakon1600-01502285;Solian (TN);HMS3884A09;AMISULPRIDE [MART.];SCHEMBL34126;Sulamid;Tox21_113392_1;8110R61I4U;NCGC00092310-01;Amisulprida (INN-Spanish);(S)-Amisulpride?;CAS-71675-85-9;FT-0630805;SR-01000759303-5;4-amino-5-ethanesulfonyl-n-(1-ethyl-pyrrolidin-2-ylmethyl)-2-m...
FormulaC17H27N3O4S
M.Wt369.48
SMILESCCN1C(CNC(C2=CC(S(=O)(CC)=O)=C(N)C=C2OC)=O)CCC1
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Amisulpride is an atypical antipsychotic used to treat psychosis in schizophrenia and episodes of mania in bipolar disorder. In Italy, it is also used as a treatment for dysthymia. It was introduced by Sanofi-Aventis in the 1990s. Its patent had expired by 2008 and hence generic formulations are now available.Amisulpride function primarily as a D2 and D3 receptor antagonist. It has high affinity for these receptors with dissociation constants of 2.2 nM and 2.4 nM, respectively. Although standard doses used to treat psychosis inhibit dopaminergic neurotransmission, low doses preferentially block inhibitory pre-synaptic autoreceptors.

In Vitro

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In Vivo

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References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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