HDAC3 PROTAC P7 chemical structure
Chemical structureResearch use only
CAT. NO. DC74495Featured

HDAC3 PROTAC P7

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Product overview

Description & Application

HDAC3 PROTAC P7 is a potent and selective HDAC3-directed PROTAC with IC50 of 40 nM (HDAC3 deacetylase activity), effectively induces HDAC3 degradation with DC50 of 0.6 nM in THP-1 cells (Emax=90%).

ParameterValue
Chemical NameHDAC3 PROTAC P7
SynonymsHDAC3-PROTAC-P7
FormulaC45H65N7O6S
M.Wt832.12
SMILESCCCNNC(=O)C1=CC=C(NC(=O)CCCCCCCCCCC(=O)N[C@@H](C(=O)N2C[C@H](O)CC2C(=O)N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)C(C)(C)C)C=C1
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

HDAC3 PROTAC P7 is a potent and selective HDAC3-directed PROTAC with IC50 of 40 nM (HDAC3 deacetylase activity), effectively induces HDAC3 degradation with DC50 of 0.6 nM in THP-1 cells (Emax=90%).

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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