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Small molecule tools for RNA delivery / Endosidin5(ES5)
Endosidin5(ES5) chemical structure
CAT. NO. DC60580Featured

Endosidin5(ES5)

Pack size & price

USD
TotalUS$500
Ships from ShanghaiFor research use only
Product overview

Description & Application

Endosidine 5 (ES5), is one of the most potent small molecules interferes with recycling endosomes through Annexin A6, thereby promoting the release and expression of mRNA into the cytoplasm. The delivered mRNAs is greatly enhanced via inhibition of endocytic recycling in cells and in live mice. NAV2729 (NAV) and endosidin 5 (ES5), resulted in significant enhancement (1.5–2 folds) of LNP-mediated delivery of Fluc mRNAs. Incubation of NAV and ES5 together caused modest further increases in Fluc expression in comparison to the sole application of either compound.

CAS No.Not available
Chemical NameEndosidin5(ES5)
SynonymsEndosidin5(ES5),ES-5, ES 5,Endosidin 5,Endosidin-5
SMILESCC1=CC2=NC(N/N=C/C3=CNC4=CC=CC=C34)=C(C)C=C2C=C1
FormulaC20H18N4
M.Wt314.39
Purity98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Shipping conditionShips from Shanghai; packaging confirmed at order.
PublicationTargeting Recycling Endosomes to Potentiate mRNA Lipid Nanoparticles-Nano Lett. 2024 May 1;24(17):5104-5109. doi: 10.1021/acs.nanolett.3c04415. Epub 2024 Apr 19.
Product classificationSmall molecule tools for RNA delivery
Laboratory planning

Solution Calculators

The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.

Mass = concentration × volume × molecular weight
Enter any three values to calculate the fourth.
C₁V₁ = C₂V₂
Enter any three values to calculate the fourth.
Preparing stock solutions

Quick preparation table

Solvent volumes update from the molecular weight above.

Mass1 mM5 mM10 mM
10 mg31.8076 mL6.3615 mL3.1808 mL
25 mg79.5191 mL15.9038 mL7.9519 mL
50 mg159.0381 mL31.8076 mL15.9038 mL
100 mg318.0763 mL63.6153 mL31.8076 mL
250 mg795.1907 mL159.0381 mL79.5191 mL

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Handling guidance

Shipping, storage and sampling

How is the lipid shipped, and how should I store it?
Ships from Shanghai. Storage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Pure lipid or solution — which should I choose?
Pure lipid is generally more stable during shipping and storage, so we usually recommend the pure form. A solution in ethanol or chloroform can be supplied when required by your workflow. Tell us the intended application, solvent and target concentration so the most suitable format can be confirmed.