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Small molecule tools for RNA delivery / ART558
ART558 chemical structure
CAT. NO. DC45847Featured

ART558

Pack size & price

USD
TotalUS$850
Ships from ShanghaiFor research use only
Product overview

Description & Application

ART558 is a nanomolar potent, selective, low molecular weight, allosteric DNA polymerase activity of Polθ inhibitor (IC50=7.9 nM). Inhibition of TMEJ with ART558 increases the efficiency of HDR-mediated repair on Cas9-induced DSBs, most profoundly in combination with a NHEJ/DNA-PKcs inhibitor.

CAS No.2603528-97-6
Chemical Name(2S,3R)-1-[3-cyano-6-methyl-4-(trifluoromethyl)pyridin-2-yl]-3-hydroxy-N-methyl-N-(3-methylphenyl)pyrrolidine-2-carboxamide
Synonyms(2S,3R)-1-[3-cyano-6-methyl-4-(trifluoromethyl)pyridin-2-yl]-3-hydroxy-N-methyl-N-(3-methylphenyl)py
SMILESFC(C1C([H])=C(C([H])([H])[H])N=C(C=1C#N)N1C([H])([H])C([H])([H])[C@]([H])([C@@]1([H])C(N(C([H])([H])[H])C1=C([H])C([H])=C([H])C(C([H])([H])[H])=C1[H])=O)O[H])(F)F
FormulaC21H21F3N4O2
M.Wt418.4123
Purity98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Shipping conditionShips from Shanghai; packaging confirmed at order.
PublicationNot available
Product classificationSmall molecule tools for RNA delivery
Laboratory planning

Solution Calculators

The product molecular weight is prefilled when available and remains editable. Confirm solvent compatibility and solubility before preparation.

Mass = concentration × volume × molecular weight
Enter any three values to calculate the fourth.
C₁V₁ = C₂V₂
Enter any three values to calculate the fourth.
Preparing stock solutions

Quick preparation table

Solvent volumes update from the molecular weight above.

Mass1 mM5 mM10 mM
10 mg23.8999 mL4.7800 mL2.3900 mL
25 mg59.7497 mL11.9499 mL5.9750 mL
50 mg119.4994 mL23.8999 mL11.9499 mL
100 mg238.9987 mL47.7997 mL23.8999 mL
250 mg597.4968 mL119.4994 mL59.7497 mL

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Handling guidance

Shipping, storage and sampling

How is the lipid shipped, and how should I store it?
Ships from Shanghai. Storage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Pure lipid or solution — which should I choose?
Pure lipid is generally more stable during shipping and storage, so we usually recommend the pure form. A solution in ethanol or chloroform can be supplied when required by your workflow. Tell us the intended application, solvent and target concentration so the most suitable format can be confirmed.