NMS-P293 chemical structure
Chemical structureResearch use only
CAT. NO. DC21390Featured

NMS-P293

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Product overview

Description & Application

NMS-P293 is a novel potent and selective PARP-1 inhibitor possessing >200-fold selectivity versus PARP-2; NMS-P293 inhibits hydrogen peroxide induced poly ADP-ribose (PAR) synthesis with an IC50 in the single digit nanomolar range; possesses favorable ADME properties, causes complete tumor regressions in mice bearing BRCA mutated breast cancer xenografts.

ParameterValue
Chemical NameNMS-P293
CAS No.1606996-12-6
SynonymsNMSP293，NMS P293
Formula341.45
M.WtC20H27N3O2
SMILESO=C(C1=CC=CC(CN2C3CCN(C4CCCCC4)CC3)=C1C2=O)N
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

NMS-P293 is a novel potent and selective PARP-1 inhibitor possessing >200-fold selectivity versus PARP-2; NMS-P293 inhibits hydrogen peroxide induced poly ADP-ribose (PAR) synthesis with an IC50 in the single digit nanomolar range; possesses favorable ADME properties, causes complete tumor regressions in mice bearing BRCA mutated breast cancer xenografts.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

Product documentation

View online datasheetRequest COA / MSDS

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Handling guide

2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

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