Calcifediol Datasheet | DCAPI1559

Calcifediol — Datasheet

CAT. NO. DCAPI1559

Parameter	Value
Chemical Name	Calcifediol
CAS No.	19356-17-3
Formula	C27H44O2
M.Wt	400.65
SMILES	C=C1CC[C@H](O)C/C1=C/C=C1\CCC[C@]2(C)[C@@H]([C@H](C)CCCC(C)(C)O)CC[C@@H]12
Purity	>99%
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Structure and molecular-weight basis	Formula, M.Wt and SMILES refer to anhydrous calcifediol. Lot-specific water content requires confirmation because the earlier product record used a hydrate formula and molecular weight.

Chemical identity references

Biological Activity

Calcifediol is a major circulating metabolite of vitamin D3, acting as a competitive inhibitor with an apparent Ki of 3.9 μM, suppresses PTH secretion and mRNA (ED50=2 nM).

In Vitro

Calcifediol in either liposomes or ethanolic solution has no effect on the release of the proinflammatory cytokine KC from Pseudomonas-infected murine epithelial cells. Treatment of infected, human bronchial 16-HBE cells with Calcifediol liposomes results in a significant reduction in bacterial survival[1].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

Target

Human Endogenous Metabolite

References & source

[1]. Castoldi A, et al. Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections. Eur J Pharm Biopharm. 2016 Nov 22

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.