DC Chemicals · Product datasheet

Bumetanide — Datasheet

CAT. NO. DCAPI1140

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ParameterValue
Chemical NameBumetanide
CAS No.28395-03-1
Synonyms3-(Butylamino)-4-phenoxy-5-sulfamoylbenzoic acid;Bumetanide (FDA);Bumetanide;2-phenoxy-3-butylamino-5-carboxybenzenesulfonamide;[3H]-Bumetanide;3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid;3-(butylamino-)-4-phenoxy-5-sulfamoylbenzoic acid;Bumetanida;Bumetanidum;Bumex;Burinex;Fontego;Fordiuran;Lunetoron;PF 1593;Ro 10-6338;Segurex;Aquazone;Diurama;Butinat;Yurinex;Cambiex;Bumetanidum [INN-Latin];Bumetanida [INN-Spanish];Lixil-Leo;Benzoic acid, 3-(aminosulfonyl)-5-(butylamino)-4-phenoxy-;0Y2S3XUQ5H;MLS000028457;Bumethanide;C17H20N2O5S;BENZOIC ACID, 3-(BUT
FormulaC17H20N2O5S
M.Wt364.4161
SMILESS(C1=C([H])C(C(=O)O[H])=C([H])C(=C1OC1C([H])=C([H])C([H])=C([H])C=1[H])N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])(N([H])[H])(=O)=O
Purity>99%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Bumetanide(Ro 10-6338; PF 1593) is an inhibitor of Na(+)-K(+)-2Cl(-) co-transporter (NKCC) with an IC50 of 0.6 uM.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

ntraperitoneal injection of 50 or 100 mg bumetanide/kg body weight resulted in an acute and transient hyperglycaemia. Pretreatment with 240 mg probenecid/kg body weight reduced the diuretic effect but potentiated the hyperglycaemic effect of bumetanide (50 mg/kg body weight). The glucose tolerance was impaired, and there was an elevated serum glucose and glucose/insulin ratio 2 h after a single injection of bumetanide (100 mg/kg body weight) [3].

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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