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TUG891 — Datasheet

CAT. NO. DC9981

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ParameterValue
Chemical NameTUG-891
CAS No.1374516-07-0
SynonymsTUG 891;3-{4-[(4-Fluoro-4'-methyl-2-biphenylyl)methoxy]phenyl}propanoic a cid;TUG-891;3-(4-((2-(cyanomethyl)phenyl)ethynyl)-2-fluorophenyl)propanoic acid;3-(4-((4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy)phenyl)propanoic acid;CHEMBL2386353;KB-145939;QC-4555;TUG-770;3-(4-((4-Fluoro-4-methyl-[1,1-biphenyl]-2-yl)methoxy)phenyl)-propanoic acid;4-[(4-Fluoro-4′-methyl[1,1′-biphenyl]-2-yl)methoxy]-benzenepropanoic acid;TUG891;3-(4-{[5-fluoro-2-(4-methylphenyl)phenyl]methoxy}phenyl)propanoic acid;3-(4-((4-Fluoro-4-methyl-[1,1-biphenyl]-2-yl)methoxy)phenyl)propanoic acid;4-[(4-Fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]-benzenepropanoic acid;3-[4-[[5-fluoro-2-(4-methylphenyl)phenyl]methoxy]phenyl]propanoic acid;3-(4-((4-fluoro-4'-methylbiphenyl-2-yl)methoxy)phenyl)propanoic acid;3-{4-[(4-fluoro-4'-methylbiphenyl-2-yl)methoxy]phenyl}propanoic acid;GTPL6490;3-(4-((4-Fluoro-4'-methyl-[1,1'-biphenyl]-2-yl)methoxy)phenyl)propanoic acid;10.1021/jm300215x;K 201 |;KG-0018;Not available;TUG 891|TUG891;YN9;AMY10839;CHEMBL2058533;Q27089037;C72503;AC-36080;EX-A1220;AKOS016340424;3-[4-({4-fluoro-4'-methyl-[1,1'-biphenyl]-2-yl}methoxy)phenyl]propanoic acid;3-{4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]phenyl}propanoic acid;GLXC-04922;1374516-07-0;GPU-028;HY-100881;BDBM50420167;ZEC51607;CS-6138;A920732;MFCD22421654;s6775;SCHEMBL15264542;BCP19294
FormulaC23H21FO3
M.Wt364.409450292587
SMILESC1C(C2C=CC(C)=CC=2)=C(COC2C=CC(CCC(=O)O)=CC=2)C=C(F)C=1
Purity>98%
Storage4°C for 1 year, -20°C for more than 2 years

Biological Activity

TUG-891 is a potent and selective agonist of the long chain free fatty acid (LCFA) receptor 4.

In Vitro

TUG-891 displays similar signaling properties to the LCFA α-linolenic acid at human FFA4, including stimulation of Ca2+ mobilization, β-arrestin-1 and β-arrestin-2 recruitment, and extracellular signal-regulated kinase phosphorylation. Activation of human FFA4 by TUG-891 also results in rapid phosphorylation and internalization of the receptor[1].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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