DC Chemicals · Product datasheet

BEC hydrochloride — Datasheet

CAT. NO. DC9964

Product page and current package options

ParameterValue
Chemical NameBEC HCl
CAS No.222638-67-7
SynonymsL-Cysteine,S-(2-boronoethyl)-, hydrochloride (1:1);L-Cysteine,S-(2-boronoethyl)-, hydrochloride (9CI);BEC HCl;(R)-2-amino-3-((2-boronoethyl)thio)propanoic acid hydrochloride;BEC (hydrochloride);S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE;BEC hydrochloride;(2R)-2-amino-3-(2-boronoethylsulfanyl)propanoic acid hydrochloride;bec-hydrochloride;BCP25043;S-(2-Boronoethyl)-l-cysteine, HCl;(R)-2-Amino-3-(2-boronoethylthio)propanoic acid hydrochloride;(2R)-2-amino-3-{[2-(dihydroxyboranyl)ethyl]sulfanyl}propanoic acid hydrochloride
FormulaC5H13BClNO4S
M.Wt229.482
SMILESCl[H].S(C([H])([H])C([H])([H])B(O[H])O[H])C([H])([H])[C@@]([H])(C(=O)O[H])N([H])[H]
Purity>98%
Storage4°C for 1 year, -20°C for more than 2 years

Biological Activity

BEC HCl is a slow-binding and competitive Arginase II inhibitor with Ki of 0.31 μM (ph 7.5).

In Vitro

BEC HCl causes significant enhancement of NO-dependent smooth muscle relaxation in this tissue. [2] BEC HCl enhances perivascular and peribronchiolar lung inflammation, mucus metaplasia, NF-κB DNA binding, and mRNA expression of the NF-κB-driven chemokine genes CCL20 and KC, and lead to further increases in airways hyperresponsiveness. [3] In vivo: BEC HCl increased contractility in isolated myocytes from WT and NOS3 but not NOS1 knockout mice. [4]

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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