DC Chemicals · Product datasheet

Ebselen — Datasheet

CAT. NO. DC9848

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ParameterValue
Chemical Name2-Phenylbenzo[d][1,2]selenazol-3(2H)-one
CAS No.60940-34-3
Synonyms2-Phenylbenzo[d][1,2]selenazol-3(2H)-one;2-Phenyl-1,2-benzisoselenazol-3(2H)-one;Ebselen;1,2-Benzisoselenazol-3(2H)-one, 2-phenyl-;2-Phenyl-1,2-benzose;2-phenyl-1,2-benzoselenazol-3-one;CCG-39161;Ebselene;Ebseleno;Ebselenum;Harmokisane;PZ-51;SPI1005;SPI-1005;2-Phenyl-1,2-benzoisoselenazol-3(2H)-one;2-Phenyl-benzo[d]isoselenazol-3-one
FormulaC13H9NOSe
M.Wt274.17666
SMILESO=C1N(C2=CC=CC=C2)[Se]C3=C1C=CC=C3
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Ebselen is a small-molecule capsid Inhibitor of HIV-1 replication.Target:Ebselen is an organoselenium compound, as an inhibitor of HIV-1 capsid CTD dimerization. Ebselen inhibits early viral postentry events of the HIV-1 life cycle by impairing the incoming capsid uncoating process. [1] Ebselen is a non-toxic seleno-organic drug with anti-inflammatory and antioxidant properties. Ebselen is an inhibitor of inositol monophosphatase (IMPase). Ebselen permeates the blood-brain barrier and inhibits endogenous inositol monophosphatase in mouse brain. [2]

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

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References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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