DC Chemicals · Product datasheet

Alsterpaullone — Datasheet

CAT. NO. DC9838

Product page and current package options

ParameterValue
Chemical NameIndolo[3,2-d][1]benzazepin-6(5H)-one,7,12-dihydro-9-nitro-
CAS No.237430-03-4
SynonymsIndolo[3,2-d][1]benzazepin-6(5H)-one,7,12-dihydro-9-nitro-;Alsterpaullone;9-nitro-7,12-dihydro-5H-indolo[3,2-d][1]benzazepin-6-one;9-Nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5)-one;9-Nitropaullone;NSC 705701
FormulaC16H11N3O3
M.Wt293.27684
SMILESO=C1CC=2C3=C(NC2C4=CC=CC=C4N1)C=CC([N+]([O-])=O)=C3
Purity>98%
Storage4°C for 1 year, -20°C for more than 2 years

Biological Activity

Alsterpaullone (9-Nitropaullone;NSC 705701) is a potent cyclin-dependent kinases (CDK) inhibitor, with IC50s of 35 nM, 15 nM, 200 nM and 40 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p35, respectively. Alsterpaullone also competes with ATP for binding to glycogen synthase kinase-3 alpha/beta (GSK-3alpha/GSK-3beta) with an IC50 of 4 nM, with antitumor activity and potential for the treatment of neurodegenerative and proliferative disorders[1].

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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