DC Chemicals · Product datasheet

AN3365(Epetraborole) — Datasheet

CAT. NO. DC9827

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ParameterValue
Chemical NameEpetraborole HCl
CAS No.1234563-16-6
Synonyms(S)-3-(aminomethyl)-7-(3-hydroxypropoxy)benzo[c][1,2]oxaborol-1(3h)-ol;AN3365;GSK2251052 hydrochloride;GSK-2251052 hydrochloride;Epetraborole (hydrochloride);Epetraborole hydrochloride;Epetraborole HCl;MM0NZY12FA;(S)-3-(Aminomethyl)-7-(3-hydroxypropoxy)-1-hydroxy-1,3-dihydro-2,1-benzoxaborole hydrochloride;AN3365(Epetraborole);Epetraborole HCl, AN3365 HCl;1-Propanol, 3-(((3S)-3-(aminomethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaborol-7-yl)oxy)-, hy
FormulaC11H17BClNO4
M.Wt273.52
SMILESCl[H].O1B(C2C(=C([H])C([H])=C([H])C=2[C@@]1([H])C([H])([H])N([H])[H])OC([H])([H])C([H])([H])C([H])([H])O[H])O[H]
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Epetraborole hydrochloride is a novel leucyl-tRNA synthetase (LeuRS) inhibitor, which inhibits protein synthesis by binding "to the terminal adenosine ribose (A76) of leucyl-tRNA synthetase". It is intended for the treatment of infections caused by Gram-negative bacteria. Epetraborole hydrochloride is a bacteriostatic compound that can against a wide range of anaerobic and Gram-negative bacteria, including multidrug-resistant pathogens, such as extended-spectrum-β-lactamase-, metallo-β-lactamase-, and carbapenemase-producing organism.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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