DC Chemicals · Product datasheet

FCCP — Datasheet

CAT. NO. DC9753

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ParameterValue
Chemical NameCarbonyl cyanide p-trifluoromethoxyphenylhydrazone
CAS No.370-86-5
SynonymsPropanedinitrile,2-[2-[4-(trifluoromethoxy)phenyl]hydrazinylidene]-;Carbonyl Cyanide 4-(Trifluoromethoxy)phenylhydrazone;FCCP;{[4-(Trifluoromethoxy)phenyl]-hydrazono}malononitrile;2-[[4-(trifluoromethoxy)phenyl]hydrazinylidene]propanedinitrile;2-{2-[4-(trifluoromethoxy)phenyl]hydrazono}malononitrile;CARBONYL CYANIDE P-TRIFLUOROMETHOXYPHENYL HYDRAZONE;FCCP,Mesoxalonitrile 4-trifluoromethoxyphenylhydrazone;[4-(Trifluoromethoxy)phenyl]carbonohydrazonoyl Dicyanide;[4-(Trifluoromethoxy)phenylhydrazono]malononitrile;Carbonyl cyanide [4-(trifluoromethoxy)phenyl]hydrazone;Carbonyl cyanide [p-(trifluoromethoxy)phenyl]hydrazone;FCCCP;Trifluoromethoxy carbonylcyanide phenylhydrazone;Carbonyl cyanide p-trifluoromethoxyphenylhydrazone;Propanedinitrile, [[4-(trifluoromethoxy)phenyl]hydrazono]-;Propanedinitrile, ((4-(trifluoromethoxy)phenyl)hydrazono)-;Carbonyl cyanide 4-trifluoromethoxyphenylhydrazone;Carbonyl cyanide, 4-trifluoromethoxyphenylhydrazone;((4-(Trifluoro
FormulaC10H5F3N4O
M.Wt254.1681
SMILESFC(OC1C([H])=C([H])C(=C([H])C=1[H])N([H])/N=C(\C#N)/C#N)(F)F
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

FCCP is an uncoupler of oxidative phosphorylation in mitochondria.

In Vitro

FCCP (5 μM) results in a concentration-dependent decrease in Aβ and APPsβ production in K695sw cells. FCCP inhibits processing of wild-type APP. FCCP does not alter cellular ATP levels at any of the concentrations measured. The effects of FCCP on APP catabolism are independent of secondary effects on oxidative phosphorylation or the result of reduced cell viability. FCCP (5 μM or 500 nM), baf A1, and NH4Cl induce changes in Tf-Tx and Tf-F cellular fluorescence in K695 cells[1]. FCCP (200 nM) protects and enhances the follicle integrity in cat ovarian tissue during short-term in vitro culture. But FCCP does not appear to exert a beneficial or detrimental effect during ovarian tissue cryopreservation[2].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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