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Madrasin — Datasheet

CAT. NO. DC9693

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ParameterValue
Chemical NameCID 135444382
CAS No.374913-63-0
SynonymsMadrasin;2-(7-Methoxy-4-methyl-quinazolin-2-ylamino)-5,6-dimethyl-3H-pyrimidin-4-one;2-[(7-Methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-4(1H)-pyrimidinone (9CI);4(1H)-Pyrimidinone, 2-[(7-methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-(9CI);4(3H)-Pyrimidinone, 2-[(7-methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-;RNAsplicing inhibitor;SMR000135614;MLS000530636;2-[(7-methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-1H-pyrimidin-4-one;2-[(7-methoxy-4-methylquinazolin-2-yl)amino]-5,6-dimethyl-1H-pyrimidin-4-one;2-[(7-methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-4(1H)-pyrimidinone;2-((7-methoxy-4-methylquinazolin-2-yl)amino)-5,6-dimethylpyrimidin-4(3H)-one;2-[(7-methoxy-4-methylquinazolin-2-yl)amino]-5,6-dimethylpyrimidin-4(1H)-one;2-((7-methoxy-4-methylquinazolin-2-yl)amino)-5,6-dimet;CID 135444382
FormulaC16N5O2H17
M.Wt311.3385
SMILESO(C([H])([H])[H])C1C([H])=C([H])C2=C(C([H])([H])[H])N=C(N=C2C=1[H])N([H])C1=NC(C([H])([H])[H])=C(C([H])([H])[H])C(N1[H])=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly. Madrasin is cytotoxic at higher concentrations, although at lower concentrations it induces cell cycle arrest, promotes a specific reorganization of subnuclear protein localization, and modulates splicing of multiple pre-mRNAs in both HeLa and HEK293 cells.

In Vitro

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In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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