DC Chemicals · Product datasheet

A-317491 (sodium salt hydrate) — Datasheet

CAT. NO. DC9574

Product page and current package options

ParameterValue
Chemical NameA 317491;A317491;(S)-5-((3-phenoxybenzyl)(1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)benzene-1,2,4-tricarboxylic acid, sodium salt hydrate
CAS No.475205-49-3
SynonymsA 317491;A317491;(S)-5-((3-phenoxybenzyl)(1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)benzene-1,2,4-tricarboxylic acid, sodium salt hydrate
FormulaC33H29NNaO9+
M.Wt606.5739
SMILESO=C(O)C1C(C(=O)O)=CC(C(=O)O)=C(C(=O)N([C@H]2C3C=CC=CC=3CCC2)CC2C=C(OC3C=CC=CC=3)C=CC=2)C=1.O.[Na+]
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

A-317491 is a non-nucleotide P2X3 and P2X2/3 receptor antagonist, which inhibits calcium flux mediated by the receptors.It is known that P2X3 and P2X2/3 receptors stimulate the pronociceptive effects of ATP upon activation. Studies indicate that the P2X3 receptor is implicated in both neuropathic and inflammatory pain. P2X3 receptor is a promising target for therapeutic intervention in cancer patients for pain management.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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