DC Chemicals · Product datasheet

EPZ015866 — Datasheet

CAT. NO. DC9267

Product page and current package options

ParameterValue
Chemical Name2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]pyridine-4-carboxamide
CAS No.1616391-87-7
Synonyms2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-4-pyridinecarboxamide.;EPZ015866;GSK 591;GSK3203591;GSK591;2-(cyclobutylamino)-N-[(2S)-2-hydroxy-3-(1,2,3,4-tetrahydroisoquinolin-2-yl)propyl]pyridine-4-carboxamide;2-(Cyclobutylamino)-N-[(2s)-3-(3,4-Dihydroisoquinolin-2(1h)-Yl)-2-Hydroxypropyl]pyridine-4-Carboxamide;GTPL8954;BDBM178085;s8111;EPZ015866(GSK591);SB19131;GSK591, >=97% (HPLC);A14374;US9675614, 188;G;2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]pyridine-4-carboxami
FormulaC22H28N4O2
M.Wt380.4833
SMILESO([H])[C@@]([H])(C([H])([H])N([H])C(C1C([H])=C([H])N=C(C=1[H])N([H])C1([H])C([H])([H])C([H])([H])C1([H])[H])=O)C([H])([H])N1C([H])([H])C2=C([H])C([H])=C([H])C([H])=C2C([H])([H])C1([H])[H]
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

EPZ015866 is a potent and selective inhibitor of protein methyltransferase 5 (PRMT5) with an IC50 of 22 nM.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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