DC Chemicals · Product datasheet

RS-1 — Datasheet

CAT. NO. DC8839

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ParameterValue
Chemical NameRS-1
CAS No.312756-74-4
Synonyms4-Bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]benzamide;3-(Benzylsulfamoyl)-4-bromo-N-(4-bromophenyl)benzamide;RS-1;3-[(benzylamino)sulfonyl]-4-bromo-N-(4-bromophenyl)benzamide;AC1LKA12;AG-205;Oprea1_166111;Oprea1_698256;RAD51-stimulatory compound 1;RS1;4-Bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]-benzamide;3-(N-Benzylsulfamoyl)-4-bromo-N-(4-bromophenyl)benzamide;Benzamide, 4-bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]-;4-bromanyl-N-(4-bromophenyl)-3-[(phenylmethyl)sulfamoyl]benzamide;RAD51-Stimulatory Compound-1, RS-1;4-bromo-n-(4-bromophenyl)-3-(((phenylmethyl)amino)sulfonyl)benzamide;3-[(benzylamino)sulfonyl]-4-bromo-N-(4-bromophenyl)benza;RAD51-Stimulatory Compound-1;CHEMBL1598912;R0215;312756-74-4;C20H16N2O3SBr2;SCHEMBL13186460;s8234;J46;DB-316417;CCG-96390;EU-0034229;Z275140708;SR-01000395441;HY-19793;HMS1917E02;AC-35367;CS-5642;CP-0069;A912272;HB5647;SR-01000395441-1;AKOS000731000;DTXSID80359902;STL170129;NCGC00141035-01;3-(benzylsulfamoyl)-4-bromo-N-(4-bromophenyl)benzamide;EX-A1010;BCP18095;MFCD00348720;J-018355;RS-1, >=98% (HPLC);4-Bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]benzamide; 4-Bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]benzamide
FormulaC20H16Br2N2O3S
M.Wt524.2256
SMILESBrC1C([H])=C([H])C(C(N([H])C2C([H])=C([H])C(=C([H])C=2[H])Br)=O)=C([H])C=1S(N([H])C([H])([H])C1C([H])=C([H])C([H])=C([H])C=1[H])(=O)=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

RS-1 is a RAD51 activator, and also increases CRISPR/Cas9-mediated knock-in efficiencies.

In Vitro

RS-1 is a RAD51 activator, stimulating binding of hRAD51 to DNA with Kd ranging from 48 nM to 107 nM in the presence of ATP or ADP and in the absence of a nucleotide cofactor, and such an effect is not via inhibiting its ATPase activity. RS-1 (20 μM) affects the length and helical pitch of hRAD51 protein-DNA complexes. RS-1 (0, 1, 5, 10, 15, 20, and 25 μM) stimulates strand assimilation activity of hRAD51. RS-1 (7.5 μM) promotes resistance of human cells to cross-linking chemotherapy[1]. RS-1 (0, 7.5, 15 μM) increases Cas9-mediated knock-in efficiencies in rabbit embryos[2].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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