DC Chemicals · Product datasheet

HZ-1157 — Datasheet

CAT. NO. DC8834

Product page and current package options

ParameterValue
Chemical Name5-Tert-butoxyquinazoline-2,4-diaMine
CAS No.1009734-33-1
Synonyms5-tert-butoxyquinazoline-2,4-diaMine;HZ-1157;DHFR-inhibitor;5-tert-butoxyquinazoline-2,4-diaMine 2,4-Quinazolinediamine, 5-(1,1-dimethylethoxy)-;5-(tert-Butoxy)quinazoline-2,4-diamine;2,4-Quinazolinediamine, 5-(1,1-dimethylethoxy)-;AOB5039;BCP13575;BDBM50385959;AK202965;5-[(2-methylpropan-2-yl)oxy]quinazoline-2,4-diamine
FormulaC12H16N4O
M.Wt232.2816
SMILESO(C1=C([H])C([H])=C([H])C2=C1C(N([H])[H])=NC(N([H])[H])=N2)C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H]
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

HZ-1157 inhibits HCV NS3/4A protease with an IC50 of 1.0 μmol/L. HZ-1157 (4a) has a high dengue virus inhibitory activity (EC50 = 0.15 μM) and is a relatively nontoxic (CC50 > 10 μM) dengue antiviral agent[1][2].

In Vitro

HZ-1157 (4a) is known to possess a broad spectrum of biological activities, such as protein lysine methyltransferase G9a inhibition, SMN2 promoter activation, dihydrofolate reductase inhibition, and others[1][2]. Cell Viability Assay[2]. Cell Line: HZ-1157 (4a) is known to possess a broad spectrum of biological activities, such as protein lysine methyltransferase G9a inhibition, SMN2 promoter activation, dihydrofolate reductase inhibition, and others. Concentration: 0-10 μmol/L. Incubation Time: 72 h. Result: Inhibited HCV infection in vitro with an IC50 of 0.82 μmol/L.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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