DC Chemicals · Product datasheet

BX 513 hydrochloride — Datasheet

CAT. NO. DC8808

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ParameterValue
Chemical NameBX 513 hydrochloride
CAS No.1216540-18-9
SynonymsBX 513 hydrochloride;BX-513 HCl;BX 513 HCL;VUF 2274;VUF2274; BX513 hydrochloride; BX-513 hydrochloride;BX-513 hydrochloride;1216540-18-9;4-(4-CHLOROPHENYL)-4-HYDROXY-A,A-DIPHENYL-1-PIPERIDINEPENTANENITRILE HYDROCHLORIDE;AKOS024457285;DTXSID30719335;BX513Hydrochloride;BX-513;193542-65-3;AS-57268;5-[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]-2,2-diphenylpentanenitrile--hydrogen chloride (1/1);BX513 hydrochloride;BCP27909;5-[4-(4-CHLOROPHENYL)-4-HYDROXYPIPERIDIN-1-YL]-2,2-DIPHENYLPENTANENITRILE HYDROCHLORIDE;A11494;VUF 2274;5-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-2,2-diphenylpentanenitrile;hydrochloride;HY-103365;BX-513 (hydrochloride)
FormulaC28H30Cl2N2O
M.Wt481.456605434418
SMILESClC1C=CC(=CC=1)C1(CCN(CCCC(C#N)(C2C=CC=CC=2)C2C=CC=CC=2)CC1)O.Cl
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

BX-513 hydrochloride inhibits MIP-1α-induced intracellular calcium mobilization (IC50 = 2.5 μM). Selective CCR1 receptor antagonist (Ki values are 0.04, > 10, > 10 and > 10 nM for CCR1, CCR5, CXCR2 and CXCR4 receptors respectively). A full inverse agonist at US28, a HCMV-encoded chemokine receptor.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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