DC Chemicals · Product datasheet

NS-398 — Datasheet

CAT. NO. DC8806

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ParameterValue
Chemical NameNS-398
CAS No.123653-11-2
SynonymsMethanesulfonamide,N-[2-(cyclohexyloxy)-4-nitrophenyl]-;NS 398;NS-398;NS398,N-[2-(Cyclohexyloxy)-4-nitrophenyl]methanesulfonamide;N-[2-(Cyclohexyloxy)-4-nitrophenyl]methanesulfonamide;Potassium Chloride;Taisho NS 398;N-[2-(cyclohexoxy)-4-nitro-phenyl]methanesulfonamide;N-[2-(CYCLOHEXYLOXY)-4-NITROPHENYL]-METHANESULFONAMIDE;NS-398 98%;NS-398 (NS398);SCHEMBL214213;AKOS015965848;N-(2-Cyclohexyloxy-4-nitro-phenyl)-methanesulfonamide;A857428;AC-32669;DTXSID8041084;N-(2-(cyclohexyloxy)-4-nitrophenyl)methanesulfonamide;N-{2-(cyclohexyloxy)-4-[hydroxy(oxido)amino]phenyl}methanesulfonamide;n-(2-cyclohexyloxy-4-nitrophenyl)methane sulfonamide;Tocris-0942;NS-398, >=98% (HPLC), solid;NCGC00024892-01;NCGC00024892-03;IDI1_002227;CCRIS 8523;N-[2-(CYCLOHEXYLOXY)-4-NITROPHENYL]METHANE-SULFONAMIDE;Bio2_000952;SR-01000597479;DB14060;FT-0719317;HMS1990P05;BRD-K53364951-001-02-6;Methanesulfonamide, N-(2-(cyclohexyloxy)-4-nitrophenyl)-;Bio2_000472;J-004968;Methanesulfonamide, N-[2-(cyclohexyloxy)-4-nitrophenyl]-;NS-398 - CAS 123653-11-2;HMS3649O13;CCG-267631;N-(2-Cyclohexyloxy-4-nitro-phenyl)-methanesulfonamide(NS-398);EX-A2402;UNII-9SP55KM2KS;CHEMBL7162;NS00069203;HMS1362P05;9SP55KM2KS;BN163753;NCGC00024892-02;NS4;MFCD00882995;KBioSS_000604;BDBM50029593;KBio3_001067;BSPBio_001264;N-[2-(cyclohexyloxy)-4-nitrophenyl]methane sulfonamide;Q6955228;C71930;NS398;KBio3_001068;s8433;123653-11-2;HY-13913;KTDZCOWXCWUPEO-UHFFFAOYSA-N;Taisho NS-398;KBio2_000604;HMS3403P05;AKOS015900136;KBioGR_000604;CYCLOHEXYLOXY-4-NITROPHENYL)METHANESULFONAMIDE, N-(2-;SR-01000597479-1;HMS1792P05;CS-5335;N1152;N-[2-Cyclohexyloxy-4-nitrophenyl]methanesulfonamide;CHEBI:73458;GTPL8976;HMS3886L10;BCP18285;SR-01000597479-2;KBio2_005740;N-(2-Cyclohexyloxy-4-nitrophenyl)methanesulfonamide;KBio2_003172;NS-398?;Taisho NS 398; N-[2-(Cyclohexyloxy)-4-nitrophenyl]methanesulfonamide;DTXCID6021084
FormulaC13H18N2O5S
M.Wt314.36
SMILESS(C)(NC1C=CC(=CC=1OC1CCCCC1)[N+](=O)[O-])(=O)=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

NS-398 is a non-steroidal an-inflammatory agent with analgesic and antipyretic effects, and selectively inhibits prostaglandin G/H synthase 2/cyclooxygenase 2 (COX-2) activity, with an IC50 of 3.8 μM, and has no effect on COX-1 at 100 μM.

In Vitro

NS-398 is a non-steroidal an-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity, with an IC50 of 3.8 μM, and has no effect on COX-1 at 100 μM[1]. NS-398 weakly inhibits PG endoperoxide synthase activity from sheep seminal vesicle microsomes (IC50, 11 μM)[2].

In Vivo

NS-398 (0.5-10 mg/kg, p.o.) dose-dependently inhibits paw edema in rats, with an ED30 of 1.14 mg/kg, shows therapeutic effects on adjuvant arthritis (ED30, 4.69 mg/kg), exhibits dose-dependent analgesic activity (ED50, 1.65 mg/kg), and has antipyretic effect (ED50, 1.84 mg/kg) in rats. In mice, NS-398 suppresses writhing reactions induced by acetic acid with an ED50 of 8.2 mg/kg[2].

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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