DC Chemicals · Product datasheet

Lacosamide — Datasheet

CAT. NO. DC8797

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ParameterValue
Chemical NameLacosamide
CAS No.175481-36-4
SynonymsLACOSAMIDE;(2R)-2-acetamido-N-benzyl-3-methoxy-propanamide;(2R)-2-(Acetylamino)-3-methoxy-N-(phenylmethyl)propanamide;ADD 243037;Erlosamide;Harkoseride;SPM 927;(R)-2-Acetamido-N-benzyl-3-methoxypropanamide;Lacosamide solution;Erlosamide [INN];S1253_Selleck;Vimpat;(2R)-N-benzyl-2-acetaMido-3-MethoxypropanaMide;(2R)-2-acetamido-N-benzyl-3-methoxypropanamide;ADD 234037;563KS2PQY5;Propanamide, 2-(acetylamino)-3-methoxy-N-(phenylmethyl)-, (2R)-;(2R)-2-(Acetylamino)-N-benzyl-3-methoxypropanamide;(R)-2-Acetylamino-N-benzyl-3-methoxy-propionamide;harkeroside;Lacosamide [USAN:INN:BAN];ADD 2;HY-13015;Tox21_113857;LACOSAMIDE [VANDF];LACOSAMIDE (MART.);(R)-N-benzyl-2-acetamido-3-methoxypropanamide;LACOSAMIDE CV (USP-RS);CHEBI:135939;LACOSAMIDE [EP MONOGRAPH];Lacosamide 1.0 mg/ml in Acetonitrile;N03AX18;DB06218;Lacosamide- Bio-X;(R)-2-acetamido-N-benzyl-3-methoxypropionamide.;DTXSID1057666;Lacosamide;LACOSAMIDE [WHO-DD];BDBM50300204;N~2~-Acetyl-N-benzyl-O-methyl-D-serinamide;CS-0529;BL164605;Lacosamida;SPM-929;GTPL7472;(2R)-2-acetamido-3-methoxy-N-(phenylmethyl)propanamide;KS-1227;AB01559947-01;(r)-lacosamide 1;LACOSAMIDE [ORANGE BOOK];UNII-563KS2PQY5;ADD-234037;DTXCID2031455;Lacosamide (JAN/USAN/INN);175481-36-4;(R)-2-Acetylamino-N-benzyl-3-methoxypropionamide;MOTPOLY;BB 0260890;VPPJLAIAVCUEMN-GFCCVEGCSA-N;Lacosamide [USAN];LACOSAMIDE [MART.];LACOSAMIDE [USP MONOGRAPH];Vimpat (TN);ertosamide;Motpoly XR;SR-01000942286;lacosamidum;Lacosamide cv;Lacosamide Oral Solution;(R)-2-acetamido-N-benzyl-3-methoxypropionamide;LACOSAMIDE [INN];SCHEMBL35330;LACOSAMIDE (USP MONOGRAPH);LACOSAMIDE (EP MONOGRAPH);CHEMBL58323;SPM-927;(2R)-2-acetylamino-N-benzyl-3-methoxypropanamide;(R)-N-Benzyl-2-acetamido-3-methoxypropionamide;NCGC00253740-01;A3897;DEA No. 2746;AR-270/11402703;LQO;LACOSAMIDE [MI];ADD243037;(R)-2-acetamido-N-benzyl-3-methoxypropanamide;2-(Acetylamino)-3-methoxy-N-(phenylmethyl)-, (2R)-;D07299;AM808141;()-(2R)-2-(acetylamino)-N-benzyl-3-methoxypropanamide;ADD-243037;AC-22750;(R)-N-benzyl 2-acetamido-3-methoxypropionamide;SPM927;CAS-175481-36-4;LACOSAMIDE [EMA EPAR];SR-01000942286-1;LACOSAMIDE [USP-RS];Lacosamide racemate;Q420077;(+)-(2R)-2-(acetylamino)-N-benzyl-3-methoxypropanamide;BCP02197;LACOSAMIDE [JAN];(R)-N-benzyl 2-acetamido-3-methoxypropionamide,;AKOS005146274;ViMpat;LacosaMide (1.0Mg/ML in Acetonitrile)
FormulaC13H18N2O3
M.Wt250.2936
SMILESO(C([H])([H])[H])C([H])([H])[C@]([H])(C(N([H])C([H])([H])C1C([H])=C([H])C([H])=C([H])C=1[H])=O)N([H])C(C([H])([H])[H])=O
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Lacosamide is a functionalized amino acid that produces activity in the maximal electroshock seizure (MES) test, that, like some other antiepileptic drugs (AEDs), are believed to act through voltage-gated sodium channels. Lacosamide enhances the slow inactivation of voltage-gated sodium channels without affecting the fast inactivation of voltage-gated sodium channels. This inactivation prevents the channel from opening, helping end the action potential. Many antiepileptic drugs, like carbamazepine or lamotrigine, slow the recovery from inactivation and hence reduce the ability of neurons to fire action potentials.

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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