DC Chemicals · Product datasheet

Flavopiridol Hydrochloride — Datasheet

CAT. NO. DC8780

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ParameterValue
Chemical NameFlavopiridol hydrochloride
CAS No.131740-09-5
SynonymsFlavopiridol hydrochloride;(-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one hydrochloride;Flavopiridol HCl;2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]chromen-4-one,hydrochloride;Flavopiridol (Alvocidib) HCl;Flavopiridol (Hydrochloride);Flavopiridol hydrochloride(Alvocidib hydrochloride);Alvocidib hydrochloride;HL 275;HL-275;HMR-1275;MDL 107826A;NSC 649890;L-86-8276;Alvocidib HCL;NSC 649890 HCl;Flavopiridol HCI;HMR 1275;D48MS3A6N9;Alvocidib hydrochloride [USAN];DSSTox_RID_83155;DSSTox_CID_28887;DSSTox_GSID_48961;L 86 8275;Alvocidib hydrochloride (USAN);2-(2-chlorophenyl)-5,7-dihydroxy-8-((3S,4R)-3-hydroxy-1-methylpiperidin-4-yl)-4H-chromen-4-one hydrochloride;(-)-2-(2-chl
FormulaC21H21Cl2NO5
M.Wt438.3011
SMILESClC1=C([H])C([H])=C([H])C([H])=C1C1=C([H])C(C2C(=C([H])C(=C(C=2O1)[C@@]1([H])C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])[C@@]1([H])O[H])O[H])O[H])=O.Cl[H]
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Flavopiridol Hydrochloride is a broad inhibitor of CDK, competing with ATP to inhibit CDKs including CDK1, CDK2, CDK4 with IC50s of 30, 170, 100 nM, respectively.

In Vitro

Flavopiridol (2 μM) robustly induces a distinct pattern of ER stress in CLL cells that contributes to cell death through IRE1-mediated activation of ASK1 and possibly downstream caspases[1]. Flavopiridol results in potent upregulation of a number of PRGs in treatments lasting 4-24 h. Flavopiridol has and immediate and long-term effect on the expression of several PRGs. In serum starved cells re-stimulated with serum, flavopiridol also inhibits the expression of these genes, but subsequently, JUNB, GADD45B and EGR1 are upregulated in the presence of flavopiridol[2].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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