DC Chemicals · Product datasheet

PD 151746 — Datasheet

CAT. NO. DC8747

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ParameterValue
Chemical NamePD 151746
CAS No.179461-52-0
SynonymsPD 151746;2-​Propenoic acid, 3-​(5-​fluoro-​1H-​indol-​3-​yl)​-​2-​mercapto-;PD-151746;3-(5-Fluoro-1H-indol-3-yl)-2-mercapto-2-propenoic acid;3-(5-FLUORO-3-INDOLYL)-2-MERCAPTO-(Z)-2-PROPENOIC ACID;PD151746 3-(5-fluoro-1H-indol-3-yl)-2-mercapto-2-Propenoic acid;PD 151746, 96%, cell permeable, selective, calpain inhibitor;181765-30-0;s7424;AKOS030526667;SW219648-1;HY-W409181;PD-151746?;CHEMBL3221936;(Z)-3-(5-fluoro-1H-indol-3-yl)-2-sulfanylprop-2-enoic acid;SCHEMBL2322924;3-(5-Fluoro-1H-indol-3-yl)-2-mercapto-2-propenoic Acid;;(Z)-3-(5-Fluoro-1H-indol-3-yl)-2-mercaptoacrylic acid;SCHEMBL2322928;CCG-266852;179461-52-0;PD151746;3-(5-fluoro-1H-indol-3-yl)-2-sulfanylprop-2-enoic acid;(Rac)-PD 151746;NCGC00346833-03;PD 151746, >=98% (HPLC);CS-0521707;3-(5-Fluoro-3-indolyl)-2-mercapto-2-propenoic Acid;AC-33154;AS-77301;EX-A2124
FormulaC11H8FNO2S
M.Wt237.25
SMILESO=C(O)/C(S)=C/C1=CNC2=C1C=C(F)C=C2
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

PD151746 is a calpain inhibitor, shows a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM).

In Vitro

The μ-calpain inhibitor PD 151746 decreases oxLDL-induced cytotoxicity. [2]

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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