Biological Activity
UF010 is a potent and selective HADC inhibitor with IC50 ~0.06 μM, 0.1 μM, 0.5 μM and 1.5 μM for HDACs 3, 2, 1 and 8, respectively. It has > 6-fold selectivity over other HDACs.IC50 value: 0.06 μM (HDAC3), 0.1 μM (HDAC2), 0.5 μM (HDAC1), 1.5 μM(HDAC 8)Target: HDACin vitro: UF010 is a competitive inhibitor with a fast-on/slow-off HDAC-binding mechanism. UF010 induces accumulation of acetylated histones in HCT116 cells in vitro, arrests cells at G1/S transition. It inhibits proliferation of a range of cancer cell lines. UF010 activates tumor suppression mechanisms while inhibiting oncogenic pathways.
In Vitro
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In Vivo
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References & source
Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.