PTACH (NCH-51) Datasheet | DC8654

PTACH (NCH-51) — Datasheet

CAT. NO. DC8654

Parameter	Value
CAS No.	848354-66-5
Synonyms	NCH-51
Formula	C20H26N2O2S2
M.Wt	390.56
SMILES	C(SCCCCCCC(=O)NC1=NC(C2=CC=CC=C2)=CS1)(=O)C(C)C
Purity	>98%
Storage	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

PTACH (NCH-51) is a SAHA-based novel inhibitor of human HDAC. PTACH exerts potent growth inhibition against various human cancer cells, with EC50 values ranging from 1 to 10 μM.

In Vitro

In cancer cell growth inhibition assay, PTACH shows strong activity. PTACH inhibits various cancer cells with EC50 of 2.3, 9.1, 3.0, 2.6, 1.1, 4.5, 2.4, 5.0, and 4.5 μM for MDA-MB-231 breast cancer, SNB-78 central nervous system, HCT116 colon cancer, NCI-H226 lung cancer, LOX-IMVI melanoma, SK-OV-3 ovarian cancer, RXF-631L renal cancer, St-4 stomach cancer, and DU-145 prostate cancer.

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

Target

IC50 value: 1-10 μM (EC50) Target: HDAC

References & source

[1]. Suzuki T, et al. Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates. J Med Chem. 2005 Feb 24;48(4):1019-1032.

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.