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Sivelestat (sodium salt hydrate) — Datasheet

CAT. NO. DC8592

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ParameterValue
Chemical NameSivelestat sodium tetrahydrate
CAS No.201677-61-4
SynonymsSivelestat sodium;Sivelestat sodium hydrate;N-[2-[[[4-(2,2-Dimethyl-1-oxopropoxy)phenyl]sulfonyl]amino]benzoyl]-(S)-glycine monosodium salt tetrahydrate;Sivelestat sodium tetrahydrate;sodium,2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetate,tetrahydrate;EI546 sodium tetrahydrate;Elaspol;LY544349 sodium tetrahydrate;ONO5046 sodium tetrahydrate;ONO-5046.Na;UNII-737RR8Y409;Sivelestat sodium salt;Sodium sivelestat;EI546 sodium;Sivelestat (sodium tetrahydrate);LY544349 sodium;Sivelestat sodium [USAN];Sivelestat sodium (USAN);ONO5046-Na;737RR8Y409;DSSTox_CID_26727;DSSTox_RID_81857;DSSTox_GSID_46727;sodium 2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetate tetrahydrate;LY544349 Sodium Hydrate;Elaspol (TN);J-013081;Ono 5046;sodium;2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetate;tetrahydrate;CHEBI:32133;SIVELESTAT SODIUM HYDRATE [JAN];SIVELESTAT SODIUM [MART.];Glycine, N-(2-(((4-(2,2-dimethyl-1-oxopropoxy)phenyl)sulfonyl)amino)benzoyl)-, monosodium salt, tetrahydrate;Sivelestat sodium salt tetrahydrate;DTXSID0046727;BCP09535;AC-1291;D01918;sodium 2-(2-(4-(pivaloyloxy)phenylsulfonamido)benzamido)acetate tetrahydrate;Sodium ((2-(((4-((2,2-dimethylpropanoyl)oxy)phenyl)sulfonyl)amino)benzoyl)amino)acetate tetrahydrate;DTXCID8026727;Sivelestat (sodium salt hydrate);Elaspol sodium salt tetrahydrate;EX-A7814;CS-3380;A909240;Tox21_112570;AKOS015963357;LY-544349 SODIUM HYDRATE;Sivelestat sodium hydrate (JP17);s4666;EI546 sodium tetrahydrate;LY544349 sodium tetrahydrate;ONO5046 sodium tetrahydrate;ONO5046-Na;Sodium sivelestat;EI546 sodium;LY544349 sodium;Sodium [[2-[[[4-[(2,2-dimethylpropanoyl)oxy]phenyl]sulfonyl]amino]benzoyl]amino]acetate tetrahydrate;Sivelestat sodium for injection (JP17);SIVELESTAT SODIUM SALT TETRAHYDRATE [MI];EI-546;CAS-201677-61-4;SIVELESTAT SODIUM [WHO-DD];Tox21_112570_1;201677-61-4;NCGC00167577-01;Sodium ((2-(((4-((2,2-dimethylpropanoyl)oxy)phenyl)sulfonyl)amino)benzoyl)amino)acetate tetrahydrate;CHEMBL3182314;CCG-269903;ONO-5046 SODIUM HYDRATE;Q27266149;HY-17443B;Propanoic acid, 2,2-dimethyl-, 4-[[[2-[[(carboxymethyl)amino]carbonyl]phenyl]amino]sulfonyl]phenyl ester, sodium salt, hydrate (1:1:4);SIVELESTATSODIUMHYDRATE;NCGC00263570-01;AKOS015901086;FT-0748809;SIVELESTAT SODIUM (MART.);Sivelestat (sodium salt hydrate)?;G60940;5134H;Monosodium N-{2-[4-(2,2-dimethylpropanoyloxy)phenylsulfonylamino]benzoyl}aminoacetate tetrahydrate;Monosodium N-(2-(4-(2,2-dimethylpropanoyloxy)phenylsulfonylamino)benzoyl)aminoacetate tetrahydrate
FormulaC20H29N2NaO11S
M.Wt528.505836248398
SMILESS(C1C=CC(=CC=1)OC(C(C)(C)C)=O)(NC1C=CC=CC=1C(NCC(=O)[O-])=O)(=O)=O.[Na+].O.O.O.O
Purity98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Sivelestat(ONO5046; LY544349; EI546) is a competitive inhibitor of human neutrophil elastase(IC50 = 44 nM; Ki=200 nM); also inhibited leukocyte elastase obtained from rabbit, rat, hamster and mouse.ONO-5046 did not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 microM. In in vivo studies, ONO-5046 suppressed lung hemorrhage in hamster (ID50 = 82 micrograms/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which were induced by human neutrophil elastase [1]. Sivelestat sodium hydrate is an anti-neutrophil elastase inhibitor and may be one of the treatment options for acute respiratory failure due to pneumocystis pneumonia in AIDS patients [2].

In Vitro

No in vitro data are provided in the current product source. Contact us for further information.

In Vivo

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References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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