DC Chemicals · Product datasheet

Daprodustat — Datasheet

CAT. NO. DC8188

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ParameterValue
Chemical NameDaprodustat
CAS No.960539-70-2
SynonymsDaprodustat;daprodustat,GSK1278863;GSK1278863;JVR38ZM64B;N-((1,3-Dicyclohexylhexahydro-2,4,6-trioxopyrimidin-5-yl)carbonyl)glycine;(1,3-dicyclohexyl-2,4,6-trioxohexahydropyrimidine-5-carbonyl)glycine;2-[(1,3-dicyclohexyl-2,4,6-trioxo-1,3-diazinane-5-carbonyl)amino]acetic acid;Daprodustat [USAN:INN];Daprodustat (GSK1278863);Duvroq (TN);GSK 1278863;Daprodustat; GSK1278863;Daprodustat (JAN/USAN/INN);GTPL8455;BCP16766;s8171;2-[(1,3-
FormulaC19H27N3O6
M.Wt393.4342
SMILESO=C1N(C(C([H])(C(N([H])C([H])([H])C(=O)O[H])=O)C(N1C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H])=O)=O)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H]
Purity>98%
Storage2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Biological Activity

Daprodustat (GSK1278863) is an orally active hypoxia-inducible factor prolyl hydroxylase inhibitor being developed for the treatment of anemia associated with chronic kidney disease.

In Vitro

GSK1278863 is an orally administered small-molecule PHI, and stimulates endogenous EPO synthesis and induce effective erythropoiesis[1]. GSK1278863 has been shown to increase erythropoietin levels, leading to increases in hemoglobin, hematocrit and red blood cell numbers[2].

In Vivo

No in vivo data are provided in the current product source. Contact us for further information.

References & source

DC Chemicals original product information

Published experimental findings depend on the model and assay conditions. They do not guarantee equivalent performance in every application. For laboratory research use only.

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